{"id":137380,"date":"2026-01-12T17:05:07","date_gmt":"2026-01-12T17:05:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-antiviral-e-induccion-de-interferon-en-las-infecciones-por-el-virus-de-la-peste-porcina-africana\/"},"modified":"2026-01-12T17:05:07","modified_gmt":"2026-01-12T17:05:07","slug":"actividad-antiviral-e-induccion-de-interferon-en-las-infecciones-por-el-virus-de-la-peste-porcina-africana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/actividad-antiviral-e-induccion-de-interferon-en-las-infecciones-por-el-virus-de-la-peste-porcina-africana\/","title":{"rendered":"Actividad antiviral e induccion de interferon en las infecciones por el virus de la peste porcina africana."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Armas Juan  Carlos <\/strong><\/h2>\n<p>1.- Hemos demostrado que el aislado ba71.V, adaptado a crecer en la linea celular establecida vero, es sensible a la accion antiviral de los ifns. El analisis de los efectos que dichas citoquinas ejercen en los diferentes estadios del ciclo de replicacion del virus (sintesis del dna, del rna y de las proteinas), sugieren que la accion antiviral se ejerce, principalmente, a nivel de la traduccion. No podemos descartar que un cierto efecto a nivel de transcripcion sea el responsable, en parte, de los efectos conseguidos con las combinaciones del ifn 1ifn 1 y del ifn 1tnf1.  2.- Un analisis similar sobre el aislado virulento cc83 cuando infecta a una de las celulas blanco naturales del virus: el macrofago, demuestra que tambien en este sistema el vppa es sensible a la accion antiviral de los ifns. A falta de un estudio transcripcional, los efectos observados a nivel de la sintesis del dna, de la actividad dna polimerasa y de las proteinas virales, parecen indicar que tambien en este sistema la accion antiviral se ejerce, principalmente, a nivel de traduccion.  3.- El tnf, descrito como antiviral frente a otros virus en diferentes lineas celulares establecidas, no ejerce dicha actividad sobre el aislado del vppa adaptado a crecer en la linea celular establecida vero. En el sistema de los map, sin embargo, el grado de variacion observado con distintos lotes de macrofagos, y la tendencia de la combinacion del tnf con los ifns   y  a antagonizar el efecto antiviral de estos ultimos, sugieren que el tnf, mas que inhibir la replicacion del vppa, tiende a incrementarla.  4.- Los estudios sobre la capacidad inductora de ifn de los diferentes aislados del vppa cuando infectan a los map, demuestran que ninguno de los aislados es capaz de inducir ifn por encima del nivel de deteccion del ensayo (10 u\/ml), siendo, por lo tanto, malos inductores.  5.- El vppa inhibe la induccion de ifn y aumenta la produccion viral del emcv durante las coin<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad antiviral e induccion de interferon en las infecciones por el virus de la peste porcina africana.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad antiviral e induccion de interferon en las infecciones por el virus de la peste porcina africana. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Armas Juan  Carlos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Paez Abril<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Carrasco Llamas <\/li>\n<li>Rosalia Rodriguez Garcia (vocal)<\/li>\n<li>Carmen Gil Fernandez (vocal)<\/li>\n<li>Javier Benavente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Armas Juan Carlos 1.- Hemos demostrado que el aislado ba71.V, adaptado a crecer en la linea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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