{"id":137465,"date":"2026-01-12T17:05:46","date_gmt":"2026-01-12T17:05:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/importancia-de-los-puntos-fragiles-comunes-pfc-en-la-etiopatogenia-del-proceso-tumoral\/"},"modified":"2026-01-12T17:05:46","modified_gmt":"2026-01-12T17:05:46","slug":"importancia-de-los-puntos-fragiles-comunes-pfc-en-la-etiopatogenia-del-proceso-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/importancia-de-los-puntos-fragiles-comunes-pfc-en-la-etiopatogenia-del-proceso-tumoral\/","title":{"rendered":"Importancia de los puntos fragiles comunes (pfc) en la etiopatogenia del proceso tumoral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sira Moreno Laguna <\/strong><\/h2>\n<p>El objetivo fundamental de este trabajo fue establecer la existencia de una relacion entre los pfc y el cancer.  para ello se selecciono, siguiendo un escrupuloso protocolo una poblacion control y una tumoral. Se demostro una inestabilidad genetica significativamente mayor en la poblacion tumoral, en parte debida a fallos en reparacion y\/o replicacion del adn, y que se manifestaba como inestabilidad cromosomica al ser expuesta al efecto de la afidicolina. Este incremento era mayor en una poblacion tumoral maligna (astrocitomas grado iii y iv) frente a una benigna (meningiomas) tras un exhaustivo analisis de la distribucion de lesiones cromosomicas se demostro que el incremento de la inestabilidad en las poblaciones tumorales era debido a una mayor expresion de pfc y a la aparicion de pfc especificos: fra17q23 en el grupo de astrocitomas y fra22q12 y fra11p13 en meningiomas. Es importante se\u00f1alar la especial implicacion del fra22q12 en meningiomas ya que el gen responsable esta localizado en esta region (22q12-qter). Y podria estar indicando la predisposicion a la perdida de hederozigosis de esta secuencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Importancia de los puntos fragiles comunes (pfc) en la etiopatogenia del proceso tumoral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Importancia de los puntos fragiles comunes (pfc) en la etiopatogenia del proceso tumoral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sira Moreno Laguna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Andres Sanchez Cascos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Bello Gonzalez M. Josefa (secretario) <\/li>\n<li>Carmen Rivas Manga (vocal)<\/li>\n<li> Abrisqueta Zarrabe Jos\u00e9 Antonio (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sira Moreno Laguna El objetivo fundamental de este trabajo fue establecer la existencia de una relacion entre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,962,1027,156],"tags":[24538,116232,252025,14778,91161],"class_list":["post-137465","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-genetica","category-oncologia","category-patologia","tag-abrisqueta-zarrabe-jose-antonio","tag-andres-sanchez-cascos","tag-bello-gonzalez-m-josefa-secretario","tag-carmen-rivas-manga","tag-sira-moreno-laguna"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/137465","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=137465"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/137465\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=137465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=137465"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=137465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}