{"id":13751,"date":"2001-12-11T00:00:00","date_gmt":"2001-12-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dislipemia-diabetica-evaluacion-y-tratamiento\/"},"modified":"2001-12-11T00:00:00","modified_gmt":"2001-12-11T00:00:00","slug":"dislipemia-diabetica-evaluacion-y-tratamiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/dislipemia-diabetica-evaluacion-y-tratamiento\/","title":{"rendered":"Dislipemia diab\u00e9tica: evaluaci\u00f3n y tratamiento."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  W\u00c1\u00a4gmer Fahlin Ana M. <\/strong><\/h2>\n<p>Justificaci\u00f3n y objetivos  1,- los m\u00e9todos que determinan el colesterol de ldl (cldl), el principal objetivo terap\u00e9utico en el manejo de la dislipemia, con caros (ultracentrifugaci\u00f3n, m\u00e9todo de referencia) o imprecisos (f\u00f3rmula de friedewald, el m\u00e9todo m\u00e1s utilizado). En esta tesis se proponen dos m\u00e9todos alternativos: una f\u00f3rmula que incluye a la apolipoprote\u00edna b y un m\u00e9todo directo.  2,- algunos componentes de la dislipemia diab\u00e9tica que no se cuantifican rutinariamente son candidatos potenciales a explicar parte del riesgo cardiovascular de la diabetes. Entre ellos, en esta tesis se evalu\u00e1n la apolipoprote\u00edna b (apob), el fenotipo b de las ldl (predominio de part\u00edculas peque\u00f1as y densas) y la lipemia postprandial, as\u00ed como marcadores de estos componentes que sean determinables en la pr\u00e1ctica cl\u00ednica.  3,- el tratamiento farmacol\u00f3gico \u00f3ptimo de la dislipemia diab\u00e9tica no est\u00e1 definido. En la presente tesis se comparan los efectos de una estatina, un fibrato y su combinaci\u00f3n sobre los distintos componentes de la dislipermia diab\u00e9tica.  resultados y conclusiones  1,- la f\u00f3rmula de friedewald infraestima el cldl (error &gt; 4% respecto al m\u00e9todo de referencia) en un 67% de los pacientes con diabetes tipo 2. sin embargo, la estimaci\u00f3n del cldl mediante una f\u00f3rmula alternativa que incluye a la apob, el error es menor, lo que deriva en una mejor clasifiaci\u00f3n de los pacientes y una m\u00e1s adecuada actitud terap\u00e9utica. No obstante, s\u00f3lo el m\u00e9todo directo de medici\u00f3n del cldl muestra un error &lt;4% a concentraciones de cldl bajas o moderdamente elevadas en las que se toman decisiones terap\u00e9uticas, por lo que podr\u00eda consideraser una altenativa a la f\u00f3rmula de friedwald a estas concentraciones.  2,- los triglic\u00e9ridos (&gt;1,7 mmol\/l) y la raz\u00f3n cldl\/apob (&lt;1,3) son los mejores predictores del fenotipo b de las ldl.  Y guardan una moderada y buena concordancia, respectivamente, con el m\u00e9todo de refe<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dislipemia diab\u00e9tica: evaluaci\u00f3n y tratamiento.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dislipemia diab\u00e9tica: evaluaci\u00f3n y tratamiento. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  W\u00c1\u00a4gmer Fahlin Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Ordo\u00f1ez Llanos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Rubies prat <\/li>\n<li>francesc Gonz\u00e1lez sastre (vocal)<\/li>\n<li>riitta Taskinen marja (vocal)<\/li>\n<li>assumpta Caix?s pedrag\u00f3s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de W\u00c1\u00a4gmer Fahlin Ana M. Justificaci\u00f3n y objetivos 1,- los m\u00e9todos que determinan el colesterol de ldl (cldl), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,851,139],"tags":[44522,13646,44520,8442,44521,44519],"class_list":["post-13751","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-endocrinologia","category-medicina-interna","tag-assumpta-caixs-pedragos","tag-francesc-gonzalez-sastre","tag-jordi-ordonez-llanos","tag-juan-rubies-prat","tag-riitta-taskinen-marja","tag-wagmer-fahlin-ana-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13751","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13751"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13751\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13751"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13751"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13751"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}