{"id":13765,"date":"2018-03-09T09:00:10","date_gmt":"2018-03-09T09:00:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-los-factores-clinicos-e-inmunohistoquimicos-en-la-recidiva-precoz-del-carcinoma-ductal-infiltrante-de-mama\/"},"modified":"2018-03-09T09:00:10","modified_gmt":"2018-03-09T09:00:10","slug":"valor-pronostico-de-los-factores-clinicos-e-inmunohistoquimicos-en-la-recidiva-precoz-del-carcinoma-ductal-infiltrante-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-los-factores-clinicos-e-inmunohistoquimicos-en-la-recidiva-precoz-del-carcinoma-ductal-infiltrante-de-mama\/","title":{"rendered":"Valor pronostico de los factores clinicos e inmunohistoquimicos en la recidiva precoz del carcinoma ductal infiltrante de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Louredo Mendez Angel Martin <\/strong><\/h2>\n<p>Justificacion  los par\u00e1metros de pr\u00f3nostico cl\u00e1sicos no simpre predicen adecuadamente la evoluci\u00f3n cl\u00ednica del c\u00e1ncer de mama, por tanto, se hace necesario la valoraci\u00f3n de otros par\u00e1metros, entre los que destacan ciertos marcadores tumorales moleculares (re, rpg, ps2, hsp27, egrf, c-erbb-2, ki-67, pcna, p53, catepsina d y glicoprote\u00edna p).  objetivos  1,- el an\u00e1lisis de la posible asociaci\u00f3n entre los diferentes marcadores tumorales moleculares.  2,- la comparaci\u00f3n de la capacidad para pronosticar recidivas precoces (36 meses postcirug\u00eda).  3,- la valoraci\u00f3n de los marcadores tumorales con relaci\u00f3n a los par\u00e1metros de pron\u00f3stico cl\u00e1sicos.  4,- la selecci\u00f3n del mejor marcador y\/o asociaci\u00f3n de marcadores que permitan establecer un valor pron\u00f3stico.  material y m\u00e9todos  estudio de cohorte ambispectivo. Per\u00edodo comprendido entre enero de 1992 a diciembre de 1999. Participaron 108 pacientes intervenidas por c\u00e1ncer ductal infiltrante con una edad media de 62,1 a\u00f1os (ic al 95% = 59,8-64,3). la determinaci\u00f3n inmunohistoqu\u00edmica se realiz\u00f3 en muestras parafinadas por el m\u00e9todo pap (peroxidasa antiperoxidas) y abc (avidina biotina peroxidasa) empleando anticuerpos monoclonales. Se estableci\u00f3 un punto de corte del 10% de las c\u00e9lulas te\u00f1idas para el re, rpg, ps2, hsp27, egfr, c-erbb-2, p-53, catepsina d y glicoprote\u00edna p. Para los ant\u00edgenos ki-67 y pcna, bas\u00e1ndonos en la mediana del porcentaje de c\u00e9lulas tumorales con tinci\u00f3n nuclear positiva, se establecieron dos grupos:  1,- bajo \u00edndice de proliferaci\u00f3n celular, a un valor por debajo de la mediana .  2,- elevado \u00edndice de proliferaci\u00f3n celular, a un valor por encima de la mediana.  el an\u00e1lisis estad\u00edstico fue realizado con el programa spss. Se analiz\u00f3 la asociaci\u00f3n entre los marcadores tumorales moleculares y con el grado histol\u00f3gico y nuclear (scarff-bloom) y con la estadificaci\u00f3n tnm. Para el c\u00e1lculo del estad\u00edstico de contraste en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pronostico de los factores clinicos e inmunohistoquimicos en la recidiva precoz del carcinoma ductal infiltrante de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pronostico de los factores clinicos e inmunohistoquimicos en la recidiva precoz del carcinoma ductal infiltrante de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Louredo Mendez Angel Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1lvaro Larrad Jim\u00e9nez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Balibrea  cantero <\/li>\n<li>Juan  Manuel San roman teran (vocal)<\/li>\n<li>Manuel G\u00f3nzalez bar\u00f3n (vocal)<\/li>\n<li>Juan  Manuel Bell\u00f3n caneiro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Louredo Mendez Angel Martin Justificacion los par\u00e1metros de pr\u00f3nostico cl\u00e1sicos no simpre predicen adecuadamente la evoluci\u00f3n cl\u00ednica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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