{"id":13783,"date":"2018-03-09T09:00:11","date_gmt":"2018-03-09T09:00:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-del-fenotipo-inmonologico-en-la-leucemia-linfatica-cronica-b\/"},"modified":"2018-03-09T09:00:11","modified_gmt":"2018-03-09T09:00:11","slug":"valor-pronostico-del-fenotipo-inmonologico-en-la-leucemia-linfatica-cronica-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-del-fenotipo-inmonologico-en-la-leucemia-linfatica-cronica-b\/","title":{"rendered":"Valor pronostico del fenotipo inmonologico en la leucemia linfatica cronica b"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raimundo Garcia Boyero <\/strong><\/h2>\n<p>El principal objetivo del trabajo es valorar si el inmunofenotipo aporta informacion pronostica en la llc-b. Se estudiaron 107 pacientes (varones 55%), edad media de 65 a\u00f1os y diagnosticados de llc seg\u00fan los criterios del grupo fab. La mayoria de los enfermos estaban asintomaticos al diagnostico (73%) y existieron pocos casos en estadios avanzados. Hubo similitud en el numero de formas morfologicas tipicas y  mixtas. La aplicaci\u00f3n del sistema de puntuacion inmunofenotipico mostro caracteristicas tipicas de llc-b (4 o 5 puntos) en el 94% de los pacientes, siendo los marcadores mas frecuentemente expesados: cd5,cd23 y cd22 debil. Las alteraciones fenotipicas que mostraron influencia pronostica negativa en el analisis univariante para la supervivencia fueron la expresion de cd13, cd25 y cd38, la expresion moderada o fuerte de cd22 e igs y un valor menor a 4 en el sistema de puntuacion, siendo los factores que mostraron influencia negativa en el analisis multivariante, la anemia, la edad avanzada y la expresion de cd25 y cd38. En los pacientes en estadio a. De binet emergen como factores negativos en el analisis multivariante de supervivencia la hipoalbuminemia y la expresion de cd25 y cd38. En conclusion, las alteraciones inmunofenotipicas, sobre todo los casos cd25 y cd38 positivos, pueden contribuir a separar grupos de riesgo en pacientes con llc-b incluso en aquellos en estadios iniciales de la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pronostico del fenotipo inmonologico en la leucemia linfatica cronica b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pronostico del fenotipo inmonologico en la leucemia linfatica cronica b <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raimundo Garcia Boyero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel \u00e1ngel Sanz Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Alberola candel <\/li>\n<li>Francisco Javier Batlle fontrodona (vocal)<\/li>\n<li>roberto Bajo g\u00f3mez (vocal)<\/li>\n<li>Mar\u00eda  consuelo Ca\u00f1ilo roldan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raimundo Garcia Boyero El principal objetivo del trabajo es valorar si el inmunofenotipo aporta informacion pronostica en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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