{"id":137952,"date":"2026-01-12T17:09:35","date_gmt":"2026-01-12T17:09:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/infusion-continua-de-compuestos-de-platino-y-5-fluorouracilo-en-cancer-de-mama-avanzado\/"},"modified":"2026-01-12T17:09:35","modified_gmt":"2026-01-12T17:09:35","slug":"infusion-continua-de-compuestos-de-platino-y-5-fluorouracilo-en-cancer-de-mama-avanzado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/infusion-continua-de-compuestos-de-platino-y-5-fluorouracilo-en-cancer-de-mama-avanzado\/","title":{"rendered":"Infusion continua de compuestos de platino y 5-fluorouracilo en cancer de mama avanzado."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Gonzalez Jos\u00e9 Federico <\/strong><\/h2>\n<p>Ensayo clinico fase ii con infusion continua de compuestos de platino y 5-fluorouracilo en cancer de mama refractario. Pautas de tratamiento. 1-cddp 20 mg\/m2\/d y 5-fu 1.000 mg\/m2\/d, ambos en 120 horas de infusion.  2-cbdca 55 mg\/m2\/d, en infusion de 4 h por 5 dias, y 5-fu 1.000 mg\/m2\/d en 120 h. Se registraron 20 respuestas objetivas (2 rc, 18 rp) de 47 pacientes evaluables en el primer grupo (42,6%), con una mediana de duracion de respuesta de 7 meses y mediana de supervivencia de 9 meses (12 meses para las respuestas). Se registraron 6 respuestas (rp) de 33 pacientes evaluables en el segundo grupo (18,2%), con una mediana de duracion de respuesta de 9 meses y mediana de supervivencia de 8 meses (12 meses las respuestas). La toxicidad observada con mas frecuencia fue hematologica (anemia y trombopenia) y nauseas-vomitos en ambas series; ademas se registro toxicidad renal y neurologica moderada en la primera serie. Los factores pronosticos que influyen significativamente en la supervivencia , en ambos grupos de tratamiento, han sido: indice de karnofsky mayor 60%, respuesta al tratamiento y ausencia de adr en primera linea. Conclusion: pautas activas en tratamiento de rescate de cancer de mama, con medianas de duracion de respuesta y supervivencia equivalentes a las mas activas de la literatura, con excelente tolerancia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Infusion continua de compuestos de platino y 5-fluorouracilo en cancer de mama avanzado.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Infusion continua de compuestos de platino y 5-fluorouracilo en cancer de mama avanzado. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Gonzalez Jos\u00e9 Federico <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Brugarolas Masllorens<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Guillermo L\u00f3pez Garc\u00eda <\/li>\n<li>Jaime Sanz Ortiz (vocal)<\/li>\n<li>Manuel G\u00f3nzalez Bar\u00f3n (vocal)<\/li>\n<li>Gerardo Zornoza Celaya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Gonzalez Jos\u00e9 Federico Ensayo clinico fase ii con infusion continua de compuestos de platino y 5-fluorouracilo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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