{"id":137974,"date":"2026-01-12T17:09:42","date_gmt":"2026-01-12T17:09:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-monocitaria-en-la-cirrosis-biliar-primaria\/"},"modified":"2026-01-12T17:09:42","modified_gmt":"2026-01-12T17:09:42","slug":"funcion-monocitaria-en-la-cirrosis-biliar-primaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/funcion-monocitaria-en-la-cirrosis-biliar-primaria\/","title":{"rendered":"Funcion monocitaria en la cirrosis biliar primaria."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Larrea Leoz M. Esther <\/strong><\/h2>\n<p>En el presente estudio hemos observado que la produccion \u00abin vitro\u00bb del factor de necrosis tumoral-alpha (tnf-alpha) por celulas mononucleares de sangre periferica (cmsp) estimuladas con lipopolisacarido, asi como los niveles sericos del mismo estan elevados en pacientes con cirrosis biliar primaria (cbp). La produccion de il-1 e il-6 por cmsp estimuladas tiende a estar aumentada respecto a controles sanos, aunque no se observaron diferencias significativas. Existia una correlacion lineal directa entre la produccion \u00abin vitro\u00bb de fnt-alpha, il-1 e il-6. Todo ello sugiere un estado anormal de activacion monocitaria en pacientes con cbp.  dicha activacion del monocito no es debida ni a la presencia de endotoxina bacteriana serica, ni a la presencia de otros factores inespecificos en el suero de estos pacientes. Parece que tampoco es debida a una posible regulacion del monocito por linfocitos t. La produccion espontanea de fnt-alpha por cmsp es normal en pacientes con cbp, indicando un trastorno en el propio monocito de estos pacientes que les hace mas susceptibles de ser activados tras sufrir estimulacion. Los elevados niveles de tnf-alpha encontrados en los pacientes con cbp pueden estar involucrados en la patogenia de esta enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funcion monocitaria en la cirrosis biliar primaria.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funcion monocitaria en la cirrosis biliar primaria. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Larrea Leoz M. Esther <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Civeira Murillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas M. Prieto Valtue\u00f1a <\/li>\n<li>Javier Diez Martinez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Solis  Herruzo (vocal)<\/li>\n<li>Natalia Mar\u00eda Lopez Moratalia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Larrea Leoz M. Esther En el presente estudio hemos observado que la produccion \u00abin vitro\u00bb del factor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,450,139,17749,156],"tags":[11773,15059,22624,252503,13081,17764],"class_list":["post-137974","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-inmunopatologia","category-medicina-interna","category-navarra","category-patologia","tag-javier-diez-Martinez","tag-jesus-m-prieto-valtuena","tag-jose-antonio-solis-herruzo","tag-larrea-leoz-m-esther","tag-natalia-maria-lopez-moratalia","tag-pilar-civeira-murillo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/137974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=137974"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/137974\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=137974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=137974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=137974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}