{"id":138054,"date":"2026-01-12T17:10:26","date_gmt":"2026-01-12T17:10:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-con-altas-dosis-de-methotrexate-y-rescate-con-leucovorin-evaluacion-de-toxicidad-y-de-factores-de-alto-riesgo\/"},"modified":"2026-01-12T17:10:26","modified_gmt":"2026-01-12T17:10:26","slug":"tratamiento-con-altas-dosis-de-methotrexate-y-rescate-con-leucovorin-evaluacion-de-toxicidad-y-de-factores-de-alto-riesgo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-con-altas-dosis-de-methotrexate-y-rescate-con-leucovorin-evaluacion-de-toxicidad-y-de-factores-de-alto-riesgo\/","title":{"rendered":"Tratamiento con altas dosis de methotrexate y rescate con leucovorin: evaluacion de toxicidad y de factores de alto riesgo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vargas Quesada Ernesto Andres <\/strong><\/h2>\n<p>Se ha estudiado la toxicidad y los factores pronostico en el retraso de aclaramiento plasmatico de methotrexate usado a altas dosis (admtx) en los pacientes tratados entre septiembre de 1984 y diciembre de 1989 en los protocolos de osteosarcoma (6g\/m2) y linfoma no hodgkin (lnh) (3g\/m2). Se han valorado 436 ciclos en un total de 82 pacientes cuya edad media ha sido 29,2 a\u00f1os (limites 2 &#8211; 67). El diagnostico ha sido osteosarcoma en 42 pacientes y lnh en 40 pacientes. La dosis media administrada ha sido 6,19 g (limites 2-13g). La monitorizacion seriada de los niveles plasmaticos de mtx, permitio identificar a 53 ciclos (12,2%) con retraso del aclaramiento a las 48 hs. (Mayor de 3&#215;10 -7 m). Las toxicidades mas frecuentes han sido renal, hematologica y digestiva (estomatitis) con 9%, 5% y 7% respectivamente.  se ha producido 1 fallecimiento por toxicidad. Los factores pronostico de retraso en el aclaramiento plasmatico de admtx han demostrado ser la edad ( a mayor edad, menor aclaramiento) la creatinina pre-tratamientomayor de 1 mg\/dl, dosis de mtx mayor de 9 g y el antecedente de recibir cisplatino previamente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento con altas dosis de methotrexate y rescate con leucovorin: evaluacion de toxicidad y de factores de alto riesgo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento con altas dosis de methotrexate y rescate con leucovorin: evaluacion de toxicidad y de factores de alto riesgo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vargas Quesada Ernesto Andres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Brugarolas Masllorens<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Vazquez Garcia <\/li>\n<li>Alejandro Tres Sanchez (vocal)<\/li>\n<li>Andr\u00e9s Purroy Unanua (vocal)<\/li>\n<li> Rodriguez Sasiain Jos\u00e9 Miguel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vargas Quesada Ernesto Andres Se ha estudiado la toxicidad y los factores pronostico en el retraso de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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