{"id":138087,"date":"2026-01-12T17:32:46","date_gmt":"2026-01-12T17:32:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neuropata%c2%ada-retardada-inducida-por-dosificacion-local-de-organofosforados\/"},"modified":"2026-01-12T17:32:46","modified_gmt":"2026-01-12T17:32:46","slug":"neuropata%c2%ada-retardada-inducida-por-dosificacion-local-de-organofosforados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/neuropata%c2%ada-retardada-inducida-por-dosificacion-local-de-organofosforados\/","title":{"rendered":"Neuropat\u00edaretardada inducida por dosificaci\u00f3n local de organofosforados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Victoria Carrera Gonzalez <\/strong><\/h2>\n<p>Algunos organofosforados inducen polineuropat\u00eda retardada 14 d\u00edas despu\u00e9s de la intoxicaci\u00f3n. Esta polineuropat\u00eda (opidp) se inicia con la fosforilaci\u00f3n y \u00abaging\u00bb de la prote\u00edna diana de neuropat\u00eda (nte). Esta prote\u00edna se encuentra en varios tejidos y sabemos que es necesario que se inhiba un 80% de la misma en todo el sistema nervioso para que aparezcan s\u00edntomas cl\u00ednicos. Las alteraciones morfol\u00f3gicas son mas evidentes en los nervios perif\u00e9ricos. As\u00ed, pues, el lugar diana de iniciaci\u00f3n de la opidp es desconocido. En el presente trabajo se desarrolla un modelo experimental quir\u00fargico de dosificaci\u00f3n local de organofosforados neurot\u00f3xicos que permite el estudio de la neuropat\u00eda \u00fanicamente en el ax\u00f3n, modificando nte s\u00f3lo en un segmento del tronco com\u00fan del nervio ci\u00e1tico. Se realizan estudios toxicol\u00f3gicos en estas condiciones y aparece una neuropat\u00eda manifestada por la p\u00e9rdida del reflejo de retracci\u00f3n de las extremidades y ataxia. El estudio o morfol\u00f3gico muestra alteraciones similares a las descritas para la intoxicaci\u00f3n sist\u00e9mica.  se concluye que existen muchas evidencias de que el ax\u00f3n es el lugar diana de la neuropat\u00eda retardada inducida por organofosforados a trav\u00e9s de la inhibici\u00f3n y modificaci\u00f3n espec\u00edfica inicial de la nte del nervio perif\u00e9rico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neuropat\u00edaretardada inducida por dosificaci\u00f3n local de organofosforados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neuropat\u00edaretardada inducida por dosificaci\u00f3n local de organofosforados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Victoria Carrera Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/03\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eugenio Vilanova Gisbert<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Francisco Horga de la parte <\/li>\n<li>pilar Sanz nicolas (vocal)<\/li>\n<li>Manuel Repetto jimenez (vocal)<\/li>\n<li>consuelo Guerri sirera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Victoria Carrera Gonzalez Algunos organofosforados inducen polineuropat\u00eda retardada 14 d\u00edas despu\u00e9s de la intoxicaci\u00f3n. Esta polineuropat\u00eda (opidp) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[19166,9,141,1279,401],"tags":[22150,35588,27438,10751,69719,146995],"class_list":["post-138087","post","type-post","status-publish","format-standard","hentry","category-alicante","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-toxicologia","tag-consuelo-guerri-sirera","tag-eugenio-vilanova-gisbert","tag-jose-francisco-horga-de-la-parte","tag-manuel-repetto-jimenez","tag-pilar-sanz-nicolas","tag-victoria-carrera-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/138087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=138087"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/138087\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=138087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=138087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=138087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}