{"id":138126,"date":"2026-01-12T17:32:50","date_gmt":"2026-01-12T17:32:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cotrimazol-en-un-sistema-terapeutico-rectal\/"},"modified":"2026-01-12T17:32:50","modified_gmt":"2026-01-12T17:32:50","slug":"cotrimazol-en-un-sistema-terapeutico-rectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/cotrimazol-en-un-sistema-terapeutico-rectal\/","title":{"rendered":"Cotrimazol en un sistema terap\u00e9utico rectal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angela Hernandez Gallego <\/strong><\/h2>\n<p>1\u00c2\u00ba,- se reivindica un modelo de dise\u00f1o para la selecci\u00f3n de formulaciones de absorci\u00f3n rectal, que comprende las siguientes etapas por orden de actuaci\u00f3n o fases:  i,- selecci\u00f3n de ingredientes susceptibles de fabricaci\u00f3n a trav\u00e9s del ensayo de reciclaje. ii,- selecci\u00f3n de formulaciones que pasan el ensayo de estabilidad acelerada. iii,- selecci\u00f3n de formulaciones con cesi\u00f3n \u00abin vitro\u00bb por di\u00e1lisis a trav\u00e9s de membrana de celulosa.  previamente este ensayo permite seleccionar ingredientes y preferentemente sales de medicamentos. tambi\u00e9n sirve para simular no solo la absorci\u00f3n \u00abin vivo\u00bb, sino que es un buen ensayo de caducidad en condiciones de estabilidad acelerada.  2\u00c2\u00ba,- se reordenan las distintas sulfonamidas estudiadas, encontr\u00e1ndose que dos: sulfametoxazol y sulfamoxol son muy superiores en absorci\u00f3n rectal a la sulfameracina y sulfadiazina.  tambi\u00e9n se demuestra la superioridad de las sales s\u00f3dicas en cuanto a la cesi\u00f3n.  de todas las estudiadas se aprecia que la \u00f3ptima es el sulfametoxazol.  el sulfametoxazol en la f\u00f3rmula 10, no presenta caducidad de cesi\u00f3n \u00abin vitro\u00bb en estudios acelerados de hasta 105 d\u00edas.  se describe un m\u00e9todo de obtenci\u00f3n de sales s\u00f3dicas.  3\u00c2\u00ba,- se encuentra, confirm\u00e1ndose anteriores estudios, que el lactato de trimetoprim es la sal del medicamento que supera en absorci\u00f3n rectal al trimetoprim.  adem\u00e1s, por primera vez, se halla que el lactato de trimetoprim supera al trimetoprim en cuanto a biodisponibilidad relativa por v\u00eda oral.  el lactato de trimetoprim en la f\u00f3rmula 10, no presenta caducidad de cesi\u00f3n \u00abin vitro\u00bb en estudios acelerados de hasta 105 d\u00edas.  se describe un procedimiento de obtenci\u00f3n de lactato de trimetoprim.  4\u00c2\u00ba,- se inicia un prototipo nuevo de sistema terap\u00e9utico rectal, como es la c\u00e1psula dura y operculada conteniendo los principios activos sin excipiente, que muestra en todos los casos mejor biodisponibilidad relativa que los supositorios grasos.  5\u00c2\u00ba,- se describen los aditivos usuales del tipo de estabilizantes de excipientes de supositorios, y se muestran las diferencias en absorci\u00f3n y di\u00e1lisis a trav\u00e9s de membrana de celulosa, de distintas formulaciones acabadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cotrimazol en un sistema terap\u00e9utico rectal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cotrimazol en un sistema terap\u00e9utico rectal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angela Hernandez Gallego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jose Torrado Valeiras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: isabel Caire serrano <\/li>\n<li>paloma Frutos cabanillas (vocal)<\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>Manuel Guzm\u00e1n navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angela Hernandez Gallego 1\u00c2\u00ba,- se reivindica un modelo de dise\u00f1o para la selecci\u00f3n de formulaciones de absorci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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