{"id":13813,"date":"2018-03-09T09:00:14","date_gmt":"2018-03-09T09:00:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monitorizacion-inmunologica-de-enfermedad-ma%c2%adnima-residual-en-el-seguimiento-de-pacientes-sometidos-a-trasplante-alogenico-de-precursores-hematodoyeticos-por-leucemia-aguda-linfoblastica\/"},"modified":"2018-03-09T09:00:14","modified_gmt":"2018-03-09T09:00:14","slug":"monitorizacion-inmunologica-de-enfermedad-ma%c2%adnima-residual-en-el-seguimiento-de-pacientes-sometidos-a-trasplante-alogenico-de-precursores-hematodoyeticos-por-leucemia-aguda-linfoblastica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/monitorizacion-inmunologica-de-enfermedad-ma%c2%adnima-residual-en-el-seguimiento-de-pacientes-sometidos-a-trasplante-alogenico-de-precursores-hematodoyeticos-por-leucemia-aguda-linfoblastica\/","title":{"rendered":"Monitorizaci\u00f3n inmunologica de enfermedad m\u00ednima residual en el seguimiento de pacientes sometidos a trasplante alogenico de precursores hematodoyeticos por leucemia aguda linfoblastica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joaquin Sanchez Garcia <\/strong><\/h2>\n<p>El trasplante alog\u00e9nico de precursores hematopoy\u00e9ticos (taph) constituye una modalidad terape\u00fatica curativa para determinados pacientes afectos de leucemia aguda linfobl\u00e1stica (lal) de mal pron\u00f3stico. Sin embargo, la reca\u00edda leuc\u00e9mica post-trasplante es la principal causa de fallo de tratamiento, con una incidencia de 30-60% y un pron\u00f3stico infausto en la mayor\u00eda de los casos. En este estudio, hemos usado citometr\u00eda de flujo multiparam\u00e9trica para cuantificar enfermedad m\u00ednima residual (emr) en 165 muestras seriadas de m\u00e9dula \u00f3sea de 40 pacientes afectos de lal que fueron sometidos a tph de donantes familiares hla-id\u00e9nticos (n=34) o donantes hla-id\u00e9nticos no emparentados (n=6). Los aspirados medulares fueron obtenidos prospectivamente en 24 pacientes en los siguientes intervalos: al ingreso, previo al r\u00e9gimen de acondicionamiento (ra), en los d\u00edas +30, +60, +90 y subsecuentemente cada 2-3 meses. Muestras medulares en 16 pacientes en remisi\u00f3n completa (rc) despu\u00e9s de tpah, se obtuvieron al menos de forma semestral.  seis de 24 pacientes mostraron niveles positivos de emr en muestras obtenidas antes del ra con niveles que oscilaron entre 0.2 y 10% de la celularidad mononucleada medular, y por el contrario 18 pacientes fueron negativos. La supervivencia libre de enfermedad (sle) para los grupos emr(+) y emr(-) fue de 33,3% y 73,5% respectivamente (p=0,03). Durante el seguimiento post-tph, 9 pacientes mostraron niveles crecientes de emr, lo cual precedi\u00f3 1-6 meses la aparici\u00f3n de reca\u00edda medular franca, mientras que 2 pacientes mantuvieron niveles estables bajos y permanecen en rc. Adem\u00e1s, empleamos citometr\u00eda de flujo multiparam\u00e9trica para cuantificar la eficacia de las infusiones de linfocitos del donante (ild) como tratamiento de rescate post-reca\u00edda en 6 pacientes. Observamos que la \u00fanica rc mantenida se obtuvo en un paciente que recibi\u00f3 ild por ser emr(+) previo a la reca\u00edda medular franca. Concluimos que la d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monitorizaci\u00f3n inmunologica de enfermedad m\u00ednima residual en el seguimiento de pacientes sometidos a trasplante alogenico de precursores hematodoyeticos por leucemia aguda linfoblastica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monitorizaci\u00f3n inmunologica de enfermedad m\u00ednima residual en el seguimiento de pacientes sometidos a trasplante alogenico de precursores hematodoyeticos por leucemia aguda linfoblastica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joaquin Sanchez Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Torres G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Aljama garcia <\/li>\n<li>neus Villamor casas (vocal)<\/li>\n<li>julia Carracedo a\u00f1on (vocal)<\/li>\n<li> Garc\u00eda marco Jos\u00e9 Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joaquin Sanchez Garcia El trasplante alog\u00e9nico de precursores hematopoy\u00e9ticos (taph) constituye una modalidad terape\u00fatica curativa para determinados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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