{"id":138246,"date":"2026-01-12T17:33:47","date_gmt":"2026-01-12T17:33:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-regulador-del-antigeno-comun-leucocitario-en-la-activacion-linfocitaria\/"},"modified":"2026-01-12T17:33:47","modified_gmt":"2026-01-12T17:33:47","slug":"papel-regulador-del-antigeno-comun-leucocitario-en-la-activacion-linfocitaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/papel-regulador-del-antigeno-comun-leucocitario-en-la-activacion-linfocitaria\/","title":{"rendered":"Papel regulador del antigeno comun leucocitario en la activacion linfocitaria."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emili Alsinet Ramos <\/strong><\/h2>\n<p>Hemos caracterizado epitopicamente al antigeno comun leucocitario mediante un panel de siete anticuerpos monoclonales cd45. Estos anticuerpos reconocen tres epitopos diferentes: a, b y c. El epitopo c es de naturaleza sialada ya que es sensible al tratamiento con neuraminidasa. Hemos estudiado el efecto de estos anticuerpos sobre la proliferacion linfocitaria. Todos ellos son capaces de sustituir la segunda se\u00f1al, proporcionada por los monocitos, necesaria para la proliferacion de linfocitos t estimulados con ssepharose r-cd39 los anticuerpos anti-a y anti-b inhiben la proliferacion de los linfocitos b estimulados con anticuerpos anti-inmunoglobulina humana, mientras que el anticuerpo anti-c la incrementa. Hemos caracterizado funcionalmente los linfocitos cd4 segun la expresion de las isoformas cd45ra y cd45ro. Demostramos que los linfocitos cd45ro son los principales productores de il-2 e ifn-y cuando son estimulados con pdbu e ionoforo. Por otro lado la il-2 es un potente factor de crecimiento para ambas supbpoblaciones, mientras que la il-4 inhibe la proliferacion de los linfocitos cd45ro estimulados con sepharose r-cd3 y en presencia de monocitos o il-2. Esta inhibicion se debe a una interferencia de la transmision de se\u00f1ales a traves del receptor de la il-2.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel regulador del antigeno comun leucocitario en la activacion linfocitaria.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel regulador del antigeno comun leucocitario en la activacion linfocitaria. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emili Alsinet Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Gaya Puig<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Celada Cotarelo <\/li>\n<li>Ramon Vilella Pons (vocal)<\/li>\n<li>Margarida Castell Escuer (vocal)<\/li>\n<li>Jaume Martorell Pons (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emili Alsinet Ramos Hemos caracterizado epitopicamente al antigeno comun leucocitario mediante un panel de siete anticuerpos monoclonales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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