{"id":13845,"date":"2018-03-09T09:00:17","date_gmt":"2018-03-09T09:00:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-de-las-isoenzimas-de-la-metionina-adenosiltransferasa-en-la-regeneracion-hepatica-en-el-ha%c2%adgado-fetal-y-en-el-hepatoma-h35\/"},"modified":"2018-03-09T09:00:17","modified_gmt":"2018-03-09T09:00:17","slug":"regulacion-de-la-expresion-de-las-isoenzimas-de-la-metionina-adenosiltransferasa-en-la-regeneracion-hepatica-en-el-ha%c2%adgado-fetal-y-en-el-hepatoma-h35","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-de-la-expresion-de-las-isoenzimas-de-la-metionina-adenosiltransferasa-en-la-regeneracion-hepatica-en-el-ha%c2%adgado-fetal-y-en-el-hepatoma-h35\/","title":{"rendered":"Regulaci\u00f3n de la expresi\u00f3n de las isoenzimas de la metionina adenosiltransferasa en la regeneraci\u00f3n hep\u00e1tica, en el h\u00edgado fetal y en el hepatoma h35"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Covadonga Pa\u00f1eda V\u00e1zquez-prada <\/strong><\/h2>\n<p>La metionina adenosiltransferasa es un enzima fundamental para el metabolismo de la metionina y cataliza la s\u00edntesis de s-adenosil-metionina a partir de metionina y atp. Hay dos isoenzimas de la mat, la mat 1a que se expresa en el h\u00edgado adulto y la mat 2a que es de expresi\u00f3n ubicua.  durante la regeneraci\u00f3n hep\u00e1tica hay un cambio en el patr\u00f3n de expresi\u00f3n de las isoenzimas, en este trabajo se ha estudiado el efecto de las citoquinas y factores que regulan la regeneraci\u00f3n hep\u00e1tica sobre la expresi\u00f3n de las isoenzimas de la mat.  los resultados de este trabajo muestran que la il-6, el tnf-a y la ceramida, un mediador de la acci\u00f3n del tnf-a disminuyen la expresi\u00f3n de la mat 1a, mientras que los factores de crecimiento como el hgf yla insulina aumentan la expresi\u00f3n de 1a mta 2a en c\u00e9lulas hep\u00e1ticas.  por \u00faltimo se ha estudiado el efecto del tratamiento con adomet, un conocido hepatoprotector, sobre la regeneraci\u00f3n hep\u00e1tica y sobre la regeneraci\u00f3n hep\u00e1tica precedida de isquemia-reperfusi\u00f3n. Los resultados obtenidos demuestran que el tratamiento con adomet tiene efectos beneficiosos sobre la regeneraci\u00f3n hep\u00e1tica s\u00f3lo si hay un da\u00f1o hepatocelular previo a la regeneraci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la expresi\u00f3n de las isoenzimas de la metionina adenosiltransferasa en la regeneraci\u00f3n hep\u00e1tica, en el h\u00edgado fetal y en el hepatoma h35<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la expresi\u00f3n de las isoenzimas de la metionina adenosiltransferasa en la regeneraci\u00f3n hep\u00e1tica, en el h\u00edgado fetal y en el hepatoma h35 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Covadonga Pa\u00f1eda V\u00e1zquez-prada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Varela Nieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Emilio feliu <\/li>\n<li>pablo Ortiz (vocal)<\/li>\n<li>Luis \u00e1lvarez Garc\u00eda (vocal)<\/li>\n<li>paloma Mart\u00edn sanz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Covadonga Pa\u00f1eda V\u00e1zquez-prada La metionina adenosiltransferasa es un enzima fundamental para el metabolismo de la metionina y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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