{"id":138560,"date":"2026-01-12T17:36:36","date_gmt":"2026-01-12T17:36:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-sistema-opioide-en-un-modelo-animal-de-depresion-learned-helplessness\/"},"modified":"2026-01-12T17:36:36","modified_gmt":"2026-01-12T17:36:36","slug":"implicacion-del-sistema-opioide-en-un-modelo-animal-de-depresion-learned-helplessness","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-del-sistema-opioide-en-un-modelo-animal-de-depresion-learned-helplessness\/","title":{"rendered":"Implicacion del sistema opioide en un modelo animal de depresion: learned helplessness"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Purificacion Tejedor Del Real <\/strong><\/h2>\n<p>Se ha propuesto que los peptidos opioides endogenos, asi como sus receptores especificos, pueden estar envueltos en la fisiopatolog\u00eda de algunas enfermedades mentales, incluida la depresion. Por ello el planteamiento de este estudio fue investigar la posible implicacion del sistema opioide en esta patolog\u00eda utilizando un modelo animal de depresion: \u00ablearned helplessness\u00bb. Se han llevado a cabo una serie de experiencias en rata, modificando el tono opioide, elevandolo mediante la administracion de agonistas tales como la met-encefalina, leu-encefalina o bubu (agonista delta), o bien mediante la administracion de inhibidores del catabolismo de encefalinas: rb 38a y rb 38b. Otra forma de modificar el tono opioide ha sido mediante la administracion de un antagonista tipico:  naloxona. Los datos obtenidos han sido contrastados con los obtenidos tras la administracion de imipramina. Los resultados nos llevan a pensar en la existencia de un sistema opioide deficitario en pacientes deprimidos. Los inhibidores de \u00abencefalinasas\u00bb, dada su escasa tolerancia y dependencia, podrian ser una alternativa terapeutica util.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion del sistema opioide en un modelo animal de depresion: learned helplessness<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion del sistema opioide en un modelo animal de depresion: learned helplessness <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Purificacion Tejedor Del Real <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Gibert Rahola<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Javier Galiana Martinez <\/li>\n<li>Felicidad Rodriguez Sanchez (vocal)<\/li>\n<li>Leonardo Casais Martinez (vocal)<\/li>\n<li>Miguel Gutierrez Fraile (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Purificacion Tejedor Del Real Se ha propuesto que los peptidos opioides endogenos, asi como sus receptores especificos, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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