{"id":138683,"date":"2026-01-12T17:37:37","date_gmt":"2026-01-12T17:37:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-gen-de-la-protimosina-alfa-durante-el-desarrollo-y-diferenciacion-celular-caracterizacion-parcial-de-la-familia-genica-de-la-protimosina-alfa-de-rata\/"},"modified":"2026-01-12T17:37:37","modified_gmt":"2026-01-12T17:37:37","slug":"expresion-del-gen-de-la-protimosina-alfa-durante-el-desarrollo-y-diferenciacion-celular-caracterizacion-parcial-de-la-familia-genica-de-la-protimosina-alfa-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/expresion-del-gen-de-la-protimosina-alfa-durante-el-desarrollo-y-diferenciacion-celular-caracterizacion-parcial-de-la-familia-genica-de-la-protimosina-alfa-de-rata\/","title":{"rendered":"Expresion del gen de la protimosina alfa durante el desarrollo y diferenciacion celular. caracterizacion parcial de la familia genica de la protimosina alfa de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Dosil Castro <\/strong><\/h2>\n<p>En este trabajo se ha demostrado que la expresion genica de la protimosina alfa (prot alfa) experimenta fuertes disminuciones en fetos durante el desarrollo prenatal y en higado, ri\u00f1on, cerebro y testiculo durante el desarrollo postnatal. En el timo se observaron solamente variaciones moderadas a lo largo de distintos periodos postnatales.  para estudiar la posible asociacion de la prot alfa con la diferenciacion celular se analizo su expresion genica durante la diferenciacion de celulas de leucemia mieloide humana hl-60. Se comprobo que los niveles de mrna de la prot alfa disminuyen drasticamente cuando las celulas hl-60 son diferenciadas tanto a traves de la via granulocitica como monocitica, pero apenas sufren variaciones despues de la simple inhibicion de la proliferacion celular. La determinacion de la vida media del mrna de la prot alfa y de su tasa de transcripcion genica revelo que estos mecanismos no son los responsables de las variaciones en el contenido en mrna de la prot alfa durante la diferenciacion.  en la segunda parte del trabajo se demostro que en el genoma de rata existe una familia genica para la prot alfa con multiples genes y\/o pseudogenes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion del gen de la protimosina alfa durante el desarrollo y diferenciacion celular. caracterizacion parcial de la familia genica de la protimosina alfa de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion del gen de la protimosina alfa durante el desarrollo y diferenciacion celular. caracterizacion parcial de la familia genica de la protimosina alfa de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Dosil Castro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaime Gomez Marquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Germ\u00e1n Sierra Marcu\u00f1o <\/li>\n<li>Amelia Nieto Martin (vocal)<\/li>\n<li>Mar\u00eda  Teresa Miras Portugal (vocal)<\/li>\n<li>Ramon Anadon Alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Dosil Castro En este trabajo se ha demostrado que la expresion genica de la protimosina alfa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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