{"id":138873,"date":"2026-01-12T17:39:15","date_gmt":"2026-01-12T17:39:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/subpoblaciones-linfocitarias-en-lupus-eritematoso-sistemico-implicaciones-clinicas\/"},"modified":"2026-01-12T17:39:15","modified_gmt":"2026-01-12T17:39:15","slug":"subpoblaciones-linfocitarias-en-lupus-eritematoso-sistemico-implicaciones-clinicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/subpoblaciones-linfocitarias-en-lupus-eritematoso-sistemico-implicaciones-clinicas\/","title":{"rendered":"Subpoblaciones linfocitarias en lupus eritematoso sistemico. implicaciones clinicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Lopez Gomez <\/strong><\/h2>\n<p>Se han analizado 98 muestras de 43 pacientes con lupus eritematoso sistemico, realizando un analisis fenotipico de celulas mononucleares, con la intencion de ver su utilidad en la deteccion de la actividad clinica de la enfermedad y correlacionarlas con distintos subgrupos clinicos-serologicos. En los les hay una disminucion de linfocitos, de las subpoblaciones bcos19, tcd4, cd45r+, cociente t4\/t8 y un aumento de hla-dr, cd25 y bcd5+.  durante los brotes de actividad se acentua el deficit de linfocitos, de celulas cd45r+, nkcd16, bcd19 y aumentan cd8 y hladr. Estas ultimas alteraciones detectan la actividad con una eficacia igual a la de los parametros serologicos (c3, c4, dnan, vig). Hay alteraciones que diferencian a los les mas severos (renales y neurologicos) de los les mas benignos (cutaneo-articulares). Cada autoanticuerpo se asocia con distintas alteraciones fenotipicas. La edad, duracion de la enfermedad influyen escasamente en las modificaciones poblacionales. Hemos detectado una proliferacion de lgg en 4 les.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Subpoblaciones linfocitarias en lupus eritematoso sistemico. implicaciones clinicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Subpoblaciones linfocitarias en lupus eritematoso sistemico. implicaciones clinicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Lopez Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Jimenez Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Garcia Morillas <\/li>\n<li>Jes\u00fas Millan Nu\u00f1ez Cortes (vocal)<\/li>\n<li>Avelino Senra Varela (vocal)<\/li>\n<li> Martin Ruiz Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Lopez Gomez Se han analizado 98 muestras de 43 pacientes con lupus eritematoso sistemico, realizando un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1085,139],"tags":[1732,1552,2422,3407,54157,39183],"class_list":["post-138873","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-enfermedades-infecciosas","category-medicina-interna","tag-avelino-senra-varela","tag-jesus-millan-nunez-cortes","tag-juan-francisco-jimenez-alonso","tag-manuel-garcia-morillas","tag-manuel-lopez-gomez","tag-martin-ruiz-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/138873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=138873"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/138873\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=138873"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=138873"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=138873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}