{"id":139011,"date":"2026-01-12T17:40:12","date_gmt":"2026-01-12T17:40:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-secuencias-del-adn-del-virus-b-de-la-hepatitis-por-tecnicas-de-hibridacion-in-situ-en-hepatopatias-cronicas-y-carcinoma-hepatocelular\/"},"modified":"2026-01-12T17:40:12","modified_gmt":"2026-01-12T17:40:12","slug":"estudio-de-secuencias-del-adn-del-virus-b-de-la-hepatitis-por-tecnicas-de-hibridacion-in-situ-en-hepatopatias-cronicas-y-carcinoma-hepatocelular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-secuencias-del-adn-del-virus-b-de-la-hepatitis-por-tecnicas-de-hibridacion-in-situ-en-hepatopatias-cronicas-y-carcinoma-hepatocelular\/","title":{"rendered":"Estudio de secuencias del adn del virus b de la hepatitis por tecnicas de hibridacion in situ en hepatopatias cronicas y carcinoma hepatocelular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Cano Mu\u00f1oz <\/strong><\/h2>\n<p>Se investigan 142 biopsias hepaticas pertenecientes a 136 enfermos, con el metodo de hibridacion in situ con sonta biotinicada para observar la posible existencia de secuencias de genoma del virus b de la hepatitis de ellas, 101 casos mostraban evidencia serologica de contacto condicho virus, 16 tenian serolog\u00eda incompleta, y 25 tenian serolog\u00eda completamente negativa y por lo tanto se usaron como controles. La hibridacion in situ detecto material genomico viral en un alto porcentaje de enfermos con serolog\u00eda de infeccion (92.8%) asi como con serolog\u00eda de inmunidad (91.9%) y en el 16% de los controles se evalua la sensibilidad y especificidad de la tecnica en relacion con la serolog\u00eda e inmunohistoquimica, y se definen patrones de la reaccion coloreada de los casos positivos.  se discute el posible papel de la persistencia viral en relacion con la carcinogenesis del carcinoma hepatocelular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de secuencias del adn del virus b de la hepatitis por tecnicas de hibridacion in situ en hepatopatias cronicas y carcinoma hepatocelular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de secuencias del adn del virus b de la hepatitis por tecnicas de hibridacion in situ en hepatopatias cronicas y carcinoma hepatocelular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Cano Mu\u00f1oz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Moreno Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juli\u00e1n Sanz Esponera <\/li>\n<li>Asuncion Garcia Sanchez (vocal)<\/li>\n<li> Pajares Garcia Jos\u00e9 M. (vocal)<\/li>\n<li>Jos\u00e9 Mate Jimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Cano Mu\u00f1oz Se investigan 142 biopsias hepaticas pertenecientes a 136 enfermos, con el metodo de hibridacion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,986,491,11771,139],"tags":[14503,55621,6533,51109,44378,13202],"class_list":["post-139011","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-complutense-de-madrid","category-gastroenterologia","category-genetica-clinica","category-medicina-interna","tag-asuncion-garcia-sanchez","tag-jose-mate-jimenez","tag-julian-sanz-esponera","tag-pajares-garcia-jose-m","tag-rafael-cano-munoz","tag-ricardo-moreno-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/139011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=139011"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/139011\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=139011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=139011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=139011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}