{"id":139182,"date":"2026-01-12T17:42:35","date_gmt":"2026-01-12T17:42:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/presencia-del-genoma-del-virus-b-de-la-hepatitis-en-celulas-mononucleares-de-sangre-periferica-expresion-influencia-del-vdh-y-tratamiento-con-interferon-alfa-recombinante\/"},"modified":"2026-01-12T17:42:35","modified_gmt":"2026-01-12T17:42:35","slug":"presencia-del-genoma-del-virus-b-de-la-hepatitis-en-celulas-mononucleares-de-sangre-periferica-expresion-influencia-del-vdh-y-tratamiento-con-interferon-alfa-recombinante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/presencia-del-genoma-del-virus-b-de-la-hepatitis-en-celulas-mononucleares-de-sangre-periferica-expresion-influencia-del-vdh-y-tratamiento-con-interferon-alfa-recombinante\/","title":{"rendered":"Presencia del genoma del virus b de la hepatitis en celulas mononucleares de sangre periferica: expresion, influencia del vdh y tratamiento con interferon alfa recombinante."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gloria Moraleda Garcia <\/strong><\/h2>\n<p>Se estudia la presencia del genoma del virus b de la hepatitis (vbh) en celulas mononucleares de sangre periferica (cmsp) para conocer la relacion entre nivel de replicacion viral y presencia del vbh-dna en cmsp, patron de expresion del dna viral en cmsp, si el virus delta (vdh) afecta a la presencia del vbh en cmsp y conocer la dinamica del vbh en cmsp tras tratamiento con ifn alfa recombinante. La presencia del vbh-dna se analizo en muestras de cmsp de 293 pacientes (263 anti-hd negativo, 30 anti-hd positivo), 22 de ellos tratados con ifn.  ademas, en 30 pacientes se estudio el patron de expresion del vbh-dna en celulas mononucleares.  globalmente, se detecto vbh-dna en el 46% (163\/293) de los pacientes. Al dividir a los pacientes en anti-hd positivo y negativo, se encontro vbh-dna en cmsp en el 43% y 57% de los casos, respectivamente. No existieron diferencias significativas entre replicacion del vbv y presencia o ausencia del vbh-dna en cmsp. Tampoco se observaron diferencias significativas en los casos que presentaban o no vdh-rna circulante en suero con la presencia del vbh-dna en celulas mononucleares (61.5% vs 53%, respectivamente).  en las 30 muestras de cmsp en las que se estudio el patron de expresion del genoma del vbh se encontraron monomeros de conformacion lineal (3.2 kb), moleculas circulares relajadas (4.2 kb) junto con moleculas lineales bicatenarias y concatemeros del vbh-dna (union de 2 o mas moleculas del genoma viral).  al finalizar la terapia, en aquellos pacientes tratados con ifn existio un descenso significativo (p 0.05) en el porcentaje de pacientes con vbh-dna en sus cmsp frente al grupo control. Durante el seguimiento, ningun grupo experimento cambios significativos en la presencia del vbh-dna en celulas mononucleares.  en conclusion, no existe relacion entre el nivel de replicacion viral y la presencia del vbh-dna en cmsp. La presencia del genoma del vbh podria servir de reservorio del virus si<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Presencia del genoma del virus b de la hepatitis en celulas mononucleares de sangre periferica: expresion, influencia del vdh y tratamiento con interferon alfa recombinante.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Presencia del genoma del virus b de la hepatitis en celulas mononucleares de sangre periferica: expresion, influencia del vdh y tratamiento con interferon alfa recombinante. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gloria Moraleda Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Carre\u00f1o Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Arturo Fernandez Cruz <\/li>\n<li>Jaime Gosalbez Berenguer (vocal)<\/li>\n<li>Angel Ortega Nu\u00f1ez (vocal)<\/li>\n<li> Bosch Novela M. Asuncion (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gloria Moraleda Garcia Se estudia la presencia del genoma del virus b de la hepatitis (vbh) en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,35,986,17,280],"tags":[7631,723,5121,253694,253695,14398],"class_list":["post-139182","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-complutense-de-madrid","category-quimica","category-virologia","tag-angel-ortega-nunez","tag-arturo-fernandez-cruz","tag-bosch-novela-m-asuncion","tag-gloria-moraleda-garcia","tag-jaime-gosalbez-berenguer","tag-vicente-carreno-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/139182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=139182"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/139182\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=139182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=139182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=139182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}