{"id":13927,"date":"2018-03-09T09:00:24","date_gmt":"2018-03-09T09:00:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-las-tecnicas-electroqua%c2%admicas-y-quimiometricas-al-estudio-de-la-complejacion-de-peptidos-de-elevado-contenido-en-azufre\/"},"modified":"2018-03-09T09:00:24","modified_gmt":"2018-03-09T09:00:24","slug":"aplicacion-de-las-tecnicas-electroqua%c2%admicas-y-quimiometricas-al-estudio-de-la-complejacion-de-peptidos-de-elevado-contenido-en-azufre","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aplicacion-de-las-tecnicas-electroqua%c2%admicas-y-quimiometricas-al-estudio-de-la-complejacion-de-peptidos-de-elevado-contenido-en-azufre\/","title":{"rendered":"Aplicaci\u00f3n de las t\u00e9cnicas electroqu\u00edmicas y quimiom\u00e9tricas al estudio de la complejaci\u00f3n de p\u00e9ptidos de elevado contenido en azufre"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia D\u00edaz Cruz <\/strong><\/h2>\n<p>En esta tesis se han estudiado las propiedades complejantes de tres biomol\u00e9culas: el glutati\u00f3n (gsh), el hexap\u00e9ptido lys-cys-thr-cys-cys-ala (fragmento c-terminal del dominio alfa de la metalotione\u00edna i de h\u00edgado de rat\u00f3n, ft) y la metalotione\u00edna ii de zinc de h\u00edgado de conejo (mt ii). los metales pesados escogidos han sido el zn(ii) como metal esencial y el cd(ii) como metal t\u00f3xico. Para llevar a cabo tales estudios, ha sido necesario el desarrollo de una nueva metodolog\u00eda de resoluci\u00f3n multivariante de curvas con optimizaci\u00f3n de m\u00ednimos cuadrados alternos (mcr-als). Dentro de las diversas funciones desarrolladas e implementadas en el proceso, cabe destacar el desarrollo de dos nuevas restricciones en el proceso de optimizaci\u00f3n iterativo con el fin de poder aplicar tal metodolog\u00eda a datos electroqu\u00edmicos.  la mayor\u00eda de los estudios de los diferentes sistemas binarios y ternarios (cd-gsh, zn-gsh, cd-ft, zn-ft, cd,zn-ft, cd,zn-mt ii) se han llevado a cabo mediante t\u00e9cnicas electroqu\u00edmicas: voltamperometr\u00eda de onda cuadrada (swv), voltamperometr\u00eda c\u00edclica (cv) y polarograf\u00eda diferencial de impulsos (dpp). Para poder comparar los resultados obtenidos, se han utilizado t\u00e9cnicas de car\u00e1cter estructural, como la espectroscop\u00eda de dicr\u00edsmo circular (cd), resonancia magn\u00e9tica nuclear (rmn) y espectroscop\u00eda de absorci\u00f3n de rayos x de estructura fina (exafs).  del an\u00e1lisis de todos estos resultados se han podido encontrar las relaciones estequiom\u00e9tricas de los diversos complejos formados, as\u00ed como la estimaci\u00f3n de algunas de sus constantes de formaci\u00f3n. As\u00ed mismo, se han propuesto mecanismos de reducci\u00f3n electr\u00f3dica y de complejaci\u00f3n para las especies formadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n de las t\u00e9cnicas electroqu\u00edmicas y quimiom\u00e9tricas al estudio de la complejaci\u00f3n de p\u00e9ptidos de elevado contenido en azufre<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n de las t\u00e9cnicas electroqu\u00edmicas y quimiom\u00e9tricas al estudio de la complejaci\u00f3n de p\u00e9ptidos de elevado contenido en azufre <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia D\u00edaz Cruz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miquel Esteban Cortada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Barbosa torralbo <\/li>\n<li>ivana Sest\u00e1kova (vocal)<\/li>\n<li> Rodr\u00edguez fern\u00e1ndez adela rosa (vocal)<\/li>\n<li> Larrechi Garc\u00eda Mar\u00eda soledad (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia D\u00edaz Cruz En esta tesis se han estudiado las propiedades complejantes de tres biomol\u00e9culas: el glutati\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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