{"id":139325,"date":"2026-01-12T17:44:39","date_gmt":"2026-01-12T17:44:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-colestasis-experimental-sobre-la-distribucion-y-toxicidad-de-la-ciclosporina-a-correlacion-bioquimica-y-anatomo-patologica\/"},"modified":"2026-01-12T17:44:39","modified_gmt":"2026-01-12T17:44:39","slug":"efectos-de-la-colestasis-experimental-sobre-la-distribucion-y-toxicidad-de-la-ciclosporina-a-correlacion-bioquimica-y-anatomo-patologica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-la-colestasis-experimental-sobre-la-distribucion-y-toxicidad-de-la-ciclosporina-a-correlacion-bioquimica-y-anatomo-patologica\/","title":{"rendered":"Efectos de la colestasis experimental sobre la distribucion y toxicidad de la ciclosporina a. correlacion bioquimica y anatomo-patologica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Antonio Gonz\u00e1lez Correa <\/strong><\/h2>\n<p>Se ha estudiado el efecto de la ligadura experimental del coledoco en ratas en la distribucion y toxicidad de la ciclosporina. Se pone de manifiesto en los resultados un incremento de los efectos toxicos de la ciclosporina en higado y ri\u00f1on mediante determinacion de parametros anatomo-patologicos de lesion tisular. De forma similar se comprueba que la ligadura del coledoco origina en el animal de experimentacion una alteracion en el perfil plasmatico de las lipoproteinas que origina una alteracion secundaria en la union de ciclosporina a dichas lipoproteinas. Paradojicamente las lesiones histologicas no fueron dosis-dependientes probablemente por el alto rango de las concentraciones de ciclosporina utilizadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la colestasis experimental sobre la distribucion y toxicidad de la ciclosporina a. correlacion bioquimica y anatomo-patologica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la colestasis experimental sobre la distribucion y toxicidad de la ciclosporina a. correlacion bioquimica y anatomo-patologica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Antonio Gonz\u00e1lez Correa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M Isabel Lucena Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfonso Moreno Gonzalez <\/li>\n<li>Javier Galiana (vocal)<\/li>\n<li> Frutos Sanz Miguel Angel (vocal)<\/li>\n<li> De Rosario Diaz Eduardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Antonio Gonz\u00e1lez Correa Se ha estudiado el efecto de la ligadura experimental del coledoco en ratas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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