{"id":139342,"date":"2026-01-12T17:44:53","date_gmt":"2026-01-12T17:44:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/induccion-de-la-ornitina-descarboxilasa-tumoral-por-ornitina-y-efecto-inhibidor-de-14-diaminas\/"},"modified":"2026-01-12T17:44:53","modified_gmt":"2026-01-12T17:44:53","slug":"induccion-de-la-ornitina-descarboxilasa-tumoral-por-ornitina-y-efecto-inhibidor-de-14-diaminas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/induccion-de-la-ornitina-descarboxilasa-tumoral-por-ornitina-y-efecto-inhibidor-de-14-diaminas\/","title":{"rendered":"Induccion de la ornitina descarboxilasa tumoral por ornitina y efecto inhibidor de 1,4-diaminas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mates Sanchez Jos\u00e9 Manuel <\/strong><\/h2>\n<p>La actividad ornitina descarboxilasa (odc) en el carcinoma de ehrlich es maxima durante la fase logaritmica de crecimiento del tumor. Los cambios observados coinciden con cambios en los niveles de los mrnas, por lo cual los aumentos de actividad pueden estar ligados a un aumento de transcripcion. En tejidos no invadidos por el tumor (higado y ri\u00f1on) se producen cambios significativos en actividad odc. Utilizando la tecnica de la perifusion celular, la ornitina es el aminoacido de mayor efecto inductor sobre la odc. Este efecto tiene lugar a nivel post-transcripcional como se comprobo con experimentos de 35s-metionina e hibridaciones mrna-32pcdna. Las diaminas inhibidoras de odc fueron efectivas a concentraciones del rango micromolar; incluso en presencia del inductor. Las caracteristicas estructurales de estas diaminas son:  estructura 1,4-diaminas, retencion de la carga de los grupos amino; distancia n-n de unos 6 a y flexibilidad del esqueleto carbonado. Se separan 12 dansil-poliaminas por hplc en 40 minutos. Todas las diaminas se acumulan intracelularmente. El afgf inhibio (curva dosis-respuesta) la actividad odc inducida por ornitina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Induccion de la ornitina descarboxilasa tumoral por ornitina y efecto inhibidor de 1,4-diaminas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Induccion de la ornitina descarboxilasa tumoral por ornitina y efecto inhibidor de 1,4-diaminas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mates Sanchez Jos\u00e9 Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisca Mar\u00eda Sanchez Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sanchez De La Cuesta Y Alarcon Felipe <\/li>\n<li>Rafael Pe\u00f1afiel Garcia (vocal)<\/li>\n<li>Fermin Sanchez De Medina Contreras (vocal)<\/li>\n<li>Dolores Gonzalez Pakanowska (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mates Sanchez Jos\u00e9 Manuel La actividad ornitina descarboxilasa (odc) en el carcinoma de ehrlich es maxima durante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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