{"id":139431,"date":"2026-01-12T17:45:40","date_gmt":"2026-01-12T17:45:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-de-la-integridad-de-la-barrera-epitelial-corneal-efectos-de-las-lagrimas-artificiales-y-sus-conservantes\/"},"modified":"2026-01-12T17:45:40","modified_gmt":"2026-01-12T17:45:40","slug":"evaluacion-de-la-integridad-de-la-barrera-epitelial-corneal-efectos-de-las-lagrimas-artificiales-y-sus-conservantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/evaluacion-de-la-integridad-de-la-barrera-epitelial-corneal-efectos-de-las-lagrimas-artificiales-y-sus-conservantes\/","title":{"rendered":"Evaluacion de la integridad de la barrera epitelial corneal. efectos de las lagrimas artificiales y sus conservantes."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Dolores Lopez Bernal <\/strong><\/h2>\n<p>En esta tesis doctoral se describe el desarrollo de un metodo experimental para evaluar el efecto que tienen diversas lagrimas artificiales y sus conservantes sobre la barrera epitelial corneal. Este efecto se estudia, por un lado, cuantitativamente, a traves de los cambios que la exposicion continuada o repetida de la cornea a las diversas soluciones artificiales produce sobre la permeabilidad del epitelio corneal al colorante 5,6 carboxifluoresceina (cf). Por otro lado, se utiliza la microscopia electronica de barrido y de transmision para establecer los cambios morfologicos producidos tras la exposicion corneal continuada a las distintas formulaciones analizadas. Se analiza, por ultimo, la capacidad de una formulacion similar a la lagrima natural para contribuir a la recuperacion de un epitelio corneal, lesionado previamente con el conservante cloruro de benzalconio.  el analisis de los resultados indica que las soluciones que contienen como conservante cloruro de benzalconio al 0,01%, producen un da\u00f1o epitelial importante, reflejado por el incremento en la captacion corneal del colorante cf en corneas tratadas si se compara con corneas controles y por la alteracion morfologica epitelial en corneas tratadas observada con microscopia electronica. Las soluciones que llevan conservantes mas suaves como polyquad al 0,001% y timerosal al 0,004%, resultan menos perjudiciales para el epitelio corneal, produciendo un peque\u00f1o incremento en la captacion corneal de cf y una alteracion minima en la morfolog\u00eda epitelial. Las soluciones carentes de conservantes no alteran la barrera epitelial, no existiendo diferencia en la captacion de cf o en el aspecto morfologico entre las corneas tratadas con soluciones sin conservantes y los controles. Solo las soluciones con composicion ionica similar a la lagrima humana son capaces de ayudar a la regeneracion de un epitelio corneal da\u00f1ado con cloruro de benzalconio. Las conclusiones de este estu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluacion de la integridad de la barrera epitelial corneal. efectos de las lagrimas artificiales y sus conservantes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluacion de la integridad de la barrera epitelial corneal. efectos de las lagrimas artificiales y sus conservantes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Dolores Lopez Bernal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaime Miralles De Imperial Mora Figueroa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge  Luciano Ali\u00f3 Sanz <\/li>\n<li>Ramon Gutierrez Ortega (vocal)<\/li>\n<li>Manuel Canteras Jordana (vocal)<\/li>\n<li> Villegas Perez M. Paz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Dolores Lopez Bernal En esta tesis doctoral se describe el desarrollo de un metodo experimental para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,5793,17467,817,8235],"tags":[8580,33214,8239,253946,9461,8581],"class_list":["post-139431","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-fisiologia-cardiovascular","category-fisiologia-de-la-vision","category-fisiologia-humana","category-murcia","tag-jaime-miralles-de-imperial-mora-figueroa","tag-jorge-luciano-alio-sanz","tag-manuel-canteras-jordana","tag-maria-dolores-lopez-bernal","tag-ramon-gutierrez-ortega","tag-villegas-perez-m-paz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/139431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=139431"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/139431\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=139431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=139431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=139431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}