{"id":13948,"date":"2018-03-09T09:00:26","date_gmt":"2018-03-09T09:00:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-que-regulan-la-expresion-del-complejo-pre-tcr-en-la-membrana-implicacion-del-dominio-intracitoplasmico-de-la-proteina-ptalfa\/"},"modified":"2018-03-09T09:00:26","modified_gmt":"2018-03-09T09:00:26","slug":"mecanismos-moleculares-que-regulan-la-expresion-del-complejo-pre-tcr-en-la-membrana-implicacion-del-dominio-intracitoplasmico-de-la-proteina-ptalfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-moleculares-que-regulan-la-expresion-del-complejo-pre-tcr-en-la-membrana-implicacion-del-dominio-intracitoplasmico-de-la-proteina-ptalfa\/","title":{"rendered":"Mecanismos moleculares que regulan la expresi\u00f3n del complejo pre-tcr en la membrana: implicaci\u00f3n del dominio intracitoplasmico de la proteina ptalfa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yolanda Rodr\u00edguez Carrasco <\/strong><\/h2>\n<p>En la tesis doctoral presentada se ha estudiado la regulaci\u00f3n de la expresi\u00f3n y funci\u00f3n del complejo pre-tcr en humanos. En estudios realizados ex vivo y con ayuda de cultivos organot\u00edpicos, hemos observado que el complejo pre-tcr se expresa de forma transitoria, en un estadio madurativo concreto, dentro del proceso de diferenciaci\u00f3n pre-t en el timo postnatal humana. adem\u00e1s alcanza niveles muy bajos de expresi\u00f3n en la membrana. Ambas caracter\u00edsticas responden a una estricta y compleja regulaci\u00f3n de su funci\u00f3n. Hemos encontrado dos etapas de regulaci\u00f3n para el pre-tcr, una a nivel de su ensamblaje en el ret\u00edculo endopl\u00e1smico de los timocitos pre-t mediante un mecanismo de retenci\u00f3n en el mismo. La segunda etapa de regulaci\u00f3n se produce en la din\u00e1mica del complejo en la membrana plasm\u00e1tica, mediante un proceso de modulaci\u00f3n negativa constitutiva que ocurre en ausencia de estimulaci\u00f3n del pre-tcr y conlleva su p\u00e9rdida de la membrana y degradaci\u00f3n en lisosomas y en el proteasoma.  la informaci\u00f3n necesaria para que ambas etapas de regulaci\u00f3n tengan lugar se encuentra en la prote\u00edna pre-t -alpha, m\u00e1s en concreto en su regi\u00f3n intracitopl\u00e1smica. El tallo de pre-t -alpha incluye un motivo ff de interacci\u00f3n con los coat\u00f3meros en su extremo de 16 aas c-terminales, responsable de sus propiedades de retenci\u00f3n en el ret\u00edculo endopl\u00e1smico y capaz de regular la expresi\u00f3n de receptores de membrana (cd25, cd24) y complejos multim\u00e9ricos (pre-tcr, tcralfa beta). Tambi\u00e9n se encuentra en el tallo de pre-t -alpha humana un motivo consenso de endocitosis y degradaci\u00f3n lisosomal basado en tirosina (yxxz, donde z es un amino\u00e1cido hidrof\u00f3bico) que pudiera estar implicado en la modulaci\u00f3n negativa constitutiva del complejo pre-tcr.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares que regulan la expresi\u00f3n del complejo pre-tcr en la membrana: implicaci\u00f3n del dominio intracitoplasmico de la proteina ptalfa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares que regulan la expresi\u00f3n del complejo pre-tcr en la membrana: implicaci\u00f3n del dominio intracitoplasmico de la proteina ptalfa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yolanda Rodr\u00edguez Carrasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Luisa Toribio Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alberto (secretario) Varas fajardo <\/li>\n<li>balbino Jos\u00e9 Alarcon sanchez (vocal)<\/li>\n<li>Antonio De la hera mart\u00ednez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yolanda Rodr\u00edguez Carrasco En la tesis doctoral presentada se ha estudiado la regulaci\u00f3n de la expresi\u00f3n y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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