{"id":139541,"date":"2026-01-12T17:46:32","date_gmt":"2026-01-12T17:46:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-ciclosporina-a-sobre-estructuras-del-glomerulo-humano-estudio-in-vitro-analisis-morfometrico\/"},"modified":"2026-01-12T17:46:32","modified_gmt":"2026-01-12T17:46:32","slug":"efectos-de-la-ciclosporina-a-sobre-estructuras-del-glomerulo-humano-estudio-in-vitro-analisis-morfometrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-la-ciclosporina-a-sobre-estructuras-del-glomerulo-humano-estudio-in-vitro-analisis-morfometrico\/","title":{"rendered":"Efectos de la ciclosporina a sobre estructuras del glomerulo humano: estudio in vitro, analisis morfometrico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ramon Gonzalez Saavedra <\/strong><\/h2>\n<p>La ciclosporina a (csa) provoca un aumento de las resistencias vasculares renales (rvr). La rapida mejoria de la funcion renal observada al reducir la dosis o retirar el farmaco sugiere que modificaciones hemodinamicas pueden tener un papel importante en la toxicidad aguda renal. Nosotros estudiamos los efectos de la csa sobre glomerulos humanos superficiales (s) y yuxtamedulares (jm), celulas mesangiales en cultivo y citoesqueleto celular. La dopamina y el verapamil se utilizaron como agentes nefroprotectores.  la csa induce una vasoconstriccion importante de los glomerulos s (p 0,00i).  los glomerulos jm no se contraen en presencia de csa.  las celulas mesangiales se contraen de manera dosis y tiempo dependiente (p 0,0i). El esqueleto celular se desorganiza en presencia de csa. La dopamina y el verapamil inhiben los efectos contractiles inducidos por la csa in vitro.  en conclusion: la csa provoca vasoconstriccion diferencial de estructuras glomerulares in vitro; los efectos contractiles observados pueden explicar en parte la toxicidad aguda renal inducida por la csa in vivo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la ciclosporina a sobre estructuras del glomerulo humano: estudio in vitro, analisis morfometrico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la ciclosporina a sobre estructuras del glomerulo humano: estudio in vitro, analisis morfometrico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ramon Gonzalez Saavedra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Rodrigo Saez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Arribas Castrillo Jos\u00e9 Manuel <\/li>\n<li>Agustin Caro Paton Gomez (vocal)<\/li>\n<li> Maradona Hidalgo Jos\u00e9 Antonio (vocal)<\/li>\n<li>Olegario Ortiz Manchado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramon Gonzalez Saavedra La ciclosporina a (csa) provoca un aumento de las resistencias vasculares renales (rvr). La [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,8846],"tags":[9694,8877,9097,111516,27831,254053],"class_list":["post-139541","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-oviedo","tag-agustin-caro-paton-gomez","tag-arribas-castrillo-jose-manuel","tag-luis-rodrigo-saez","tag-maradona-hidalgo-jose-antonio","tag-olegario-ortiz-manchado","tag-ramon-gonzalez-saavedra"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/139541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=139541"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/139541\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=139541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=139541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=139541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}