{"id":139691,"date":"2026-01-12T17:47:55","date_gmt":"2026-01-12T17:47:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regulacion-de-la-transcripcion-del-operon-hly\/"},"modified":"2026-01-12T17:47:55","modified_gmt":"2026-01-12T17:47:55","slug":"mecanismos-de-regulacion-de-la-transcripcion-del-operon-hly","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-de-regulacion-de-la-transcripcion-del-operon-hly\/","title":{"rendered":"Mecanismos de regulacion de la transcripcion del operon hly."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yolanda Jubete Casta\u00f1eda <\/strong><\/h2>\n<p>El operon hly del plasmido phly152 se expresa en dos transcritos, un transcrito mayoritario hlyca (4kb) y un transcrito mucho mas inestable, hlycabd (8kb). Hlyr constituye un estimulador transcripcional localizado en el extremo 5 del operon hly, a 1.6 kb del promotor phly hlyr aumenta la expresion de la hemolisina entre 40 y 50 veces, dependiendo del numero de copias del plasmido en el que esta contenido el operon hly. Este efecto es consecuencia de la inhibicion de la modulacion de la transcripcion que ejerce hlym. Hlym se comporta como un modulador negativo de la transcripcion del operon hly. La region hlym es una secuencia de 220 pb situada en el gen hlyc. Mediante fusiones genicas se ha demostrado que hlym disminuye 21 veces la transcripcion iniciada en el promotor phly. La proteina hha se comporta como un represor transcripcional. Su union a hlym parece responsable de la disminucion de la expresion de hemolisina que se observa en operones hlym+. Los genes que determinan la sintesis de hemolisina activa y los genes encargados de la exportacion de la misma estan separados por un terminador de la transcripcion rho-independiente. El 88.5% de los transcritos ca acaban en el terminador hlyt. El grado de antiterminacion es independiente de la presencia de hlyr. Los genes de exportacion hlyb y hlyd se expresan en el transcrito cabd que se origina por lectura de los transcritos ca a traves de hlyt.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de regulacion de la transcripcion del operon hly.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de regulacion de la transcripcion del operon hly. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yolanda Jubete Casta\u00f1eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando De La Cruz Calahorra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Mario Hurle Gonzalez <\/li>\n<li>Timothy Thomson Okatsu (vocal)<\/li>\n<li>Felix Mar\u00eda Go\u00f1i Urcelay (vocal)<\/li>\n<li>Antonio Juarez Jimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yolanda Jubete Casta\u00f1eda El operon hly del plasmido phly152 se expresa en dos transcritos, un transcrito mayoritario [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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