{"id":13980,"date":"2018-03-09T09:00:29","date_gmt":"2018-03-09T09:00:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-polimorfismo-h-la-y-de-otros-genes-candidatos-en-la-susceptibilidad-y-curso-clinico-de-la-artritis-reumatoide\/"},"modified":"2018-03-09T09:00:29","modified_gmt":"2018-03-09T09:00:29","slug":"influencia-del-polimorfismo-h-la-y-de-otros-genes-candidatos-en-la-susceptibilidad-y-curso-clinico-de-la-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-del-polimorfismo-h-la-y-de-otros-genes-candidatos-en-la-susceptibilidad-y-curso-clinico-de-la-artritis-reumatoide\/","title":{"rendered":"Influencia del polimorfismo h la y de otros genes candidatos en la susceptibilidad y curso clinico de la artritis reumatoide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Rosa Rodriguez Perez <\/strong><\/h2>\n<p>La artritis reumatoide (ar) es una enfermedad inflamatoria cronica de naturaleza autoinmune que presenta un curso clinico muy variable. La relacion de las moleculas de clase ii del complejo mayor de histocompatibilidad humano (sistema hla) con la enfermedad esta bien establecida. Sin embargo, se han propuesto dos modelos diferentes de asociacion ar y hla,ambos atribuyen un papel fundamental a las moleculas de clase ii, pero difieren el locus concreto que consideran como primariamente asociado. Se sabe que deben existir otros factores geneticos implicados en la enfermedad, pero estos factores no se conocen bien en la actualidad. En el presente trabajo, hemos utilizado un estudio de casos y controles para comparar los dos modelos actualmente propuestos de asociacion hla y ar. Por otro lado se ha estudiado la posible implicacion de los genes ctla-4,vdr y nramp1 ya que la funcion de estas moleculas determina que puedan ser considerados genes candidatos para la susceptibilidad a la enfermedad. Ademas, en un estudio longitudinal prospectivo a diez a\u00f1os hemos estudiado la posible influencia de los factores geneticos antes mencionados en la afectacion radiologica de las articulaciones al comienzo de la enfermedad y despues de diez a\u00f1os de evolucion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del polimorfismo h la y de otros genes candidatos en la susceptibilidad y curso clinico de la artritis reumatoide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del polimorfismo h la y de otros genes candidatos en la susceptibilidad y curso clinico de la artritis reumatoide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Rosa Rodriguez Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio N\u00fa\u00f1ez Rold\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: raimundo Goberna ortiz <\/li>\n<li>Juan  d. Bautista palomas (vocal)<\/li>\n<li>federico Garrido torres-puchol (vocal)<\/li>\n<li>Javier Martin iba\u00f1ez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Rosa Rodriguez Perez La artritis reumatoide (ar) es una enfermedad inflamatoria cronica de naturaleza autoinmune que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,1737,450,139,156,877,10715],"tags":[35286,3942,45178,3496,45177,26685],"class_list":["post-13980","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-inmunologia","category-inmunopatologia","category-medicina-interna","category-patologia","category-reumatologia","category-sevilla","tag-antonio-nunez-roldan","tag-federico-garrido-torres-puchol","tag-javier-martin-ibanez","tag-juan-d-bautista-palomas","tag-maria-rosa-rodriguez-perez","tag-raimundo-goberna-ortiz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13980","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13980"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13980\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13980"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13980"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13980"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}