{"id":139882,"date":"2026-01-12T17:49:37","date_gmt":"2026-01-12T17:49:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-clinico-de-la-efectividad-y-tolerancia-de-los-nitratos\/"},"modified":"2026-01-12T17:49:37","modified_gmt":"2026-01-12T17:49:37","slug":"estudio-clinico-de-la-efectividad-y-tolerancia-de-los-nitratos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-clinico-de-la-efectividad-y-tolerancia-de-los-nitratos\/","title":{"rendered":"Estudio clinico de la efectividad y tolerancia de los nitratos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Almenar Bonet <\/strong><\/h2>\n<p>Con este trabajo se ha pretendido valorar la respuesta aguda a los nitratos (5-mononitrato de isosorbide y nitroglicerina), asi como los cambios que aparecen tras su administracion prolongada. Se han estudiado 90 pacientes, 60 con angina de esfuerzo estable y 30 con fallo cardiaco (20 cronico y 10 agudo). El el estudio fue randomizado, doble ciego, cruzado y controlado frente a placebo, durante 100 dias (en el caso de la nitroglicerina 48 horas). Se realizaron cicloergometrias ecocardiografias y medicion de presiones centrales (nitroglicerina).  segun los resultados obtenidos podemos concluir que la administracion de nitratos: 1) en pacientes con cardiopatia isquemica prolonga el tiempo de aparicion de la angina y la isquemia, no produciendo tolerancia a los 100 dias. 2) mejora hemodinamicamente al paciente con fallo cardiaco cronico reduciendo los diametros ventriculares a los 100 dias y sin producir tolerancia.  3) en perfusion continua se traduce en una atenuacion importante de sus efectos a los 48 a\u00f1os.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio clinico de la efectividad y tolerancia de los nitratos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio clinico de la efectividad y tolerancia de los nitratos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Almenar Bonet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gimeno Gascon Jos\u00e9 Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Morcillo Sanchez <\/li>\n<li>Lu\u00eds Such Belenguer (vocal)<\/li>\n<li>Juan  Antonio Ruiperez Abizanda (vocal)<\/li>\n<li> Marques Defez Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Almenar Bonet Con este trabajo se ha pretendido valorar la respuesta aguda a los nitratos (5-mononitrato [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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