{"id":139938,"date":"2026-01-12T17:50:15","date_gmt":"2026-01-12T17:50:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cefadroxilo-farmacocinetica-en-el-perro-beagle-influencia-del-ambroxol-modelos-no-lineales\/"},"modified":"2026-01-12T17:50:15","modified_gmt":"2026-01-12T17:50:15","slug":"cefadroxilo-farmacocinetica-en-el-perro-beagle-influencia-del-ambroxol-modelos-no-lineales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cefadroxilo-farmacocinetica-en-el-perro-beagle-influencia-del-ambroxol-modelos-no-lineales\/","title":{"rendered":"Cefadroxilo: farmacocinetica en el perro beagle. influencia del ambroxol. modelos no lineales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Dubon Juarez <\/strong><\/h2>\n<p>Se ha realizado un estudio de biodisponibilidad con defadroxilo, para evaluar la influencia del mucolitico ambroxol sobre la farmacocinetica del antibiotico, en el perro \u00abbeagle\u00bb, mediante un ensayo cruzado sobre 9 animales. Las muestras plasmaticas se han valorado con el metodo microbiologico para cuantificacion de sustancias con propiedades antimicrobianas.  para la realizacion del ensayo se administraron tres preparados, dos de ellos administrados por via oral: una capsula con 250 mg de cefadroxilo y otra con el mismo contenido adicionado de 15 mg de ambroxol; y una solucion con 100 mg de defadroxilo por via intravenosa.  el analisis estadistico (anova de tres vias) evalua los factores perro, periodo y preparado. No se encuentra significacion en los parametros cmax, tmax, auc y periodo de latencia entre los preparados orales, pero si aparecen diferencias significativas entre las areas bajo la curva de los preparados orales y el preparado intravenoso.  se han desarrollado los procedimientos matematicos para tratar curvas de nivel plasmatico en los que la absorcion discurre mediante cineticas no lineales. La aplicacion de los mismos concluye en que ello es debido a que los procesos de incorporacion del cefadroxilo al plasma se rigen por una cinetica de la que es parte la ecuacion de michaelis-menten.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cefadroxilo: farmacocinetica en el perro beagle. influencia del ambroxol. modelos no lineales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cefadroxilo: farmacocinetica en el perro beagle. influencia del ambroxol. modelos no lineales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Dubon Juarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pla Delfina  Jos\u00e9 M<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Esplugues Requena <\/li>\n<li>Victor Jimenez Torres (vocal)<\/li>\n<li>Eduardo Mari\u00f1o Hernandez (vocal)<\/li>\n<li>Rosendo Obach Vidal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Dubon Juarez Se ha realizado un estudio de biodisponibilidad con defadroxilo, para evaluar la influencia del 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