{"id":14024,"date":"2018-03-09T09:00:33","date_gmt":"2018-03-09T09:00:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-teoricos-de-mecanismos-y-especificidad-de-interaccion-ligando-receptor\/"},"modified":"2018-03-09T09:00:33","modified_gmt":"2018-03-09T09:00:33","slug":"estudios-teoricos-de-mecanismos-y-especificidad-de-interaccion-ligando-receptor","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-teoricos-de-mecanismos-y-especificidad-de-interaccion-ligando-receptor\/","title":{"rendered":"Estudios te\u00f3ricos de mecanismos y especificidad de interacci\u00f3n ligando-receptor"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xavier Barril Alonso <\/strong><\/h2>\n<p>La predicci\u00f3n y la comprensi\u00f3n de las interacciones entre macromol\u00e9culas biol\u00f3gicas y sus ligandos espec\u00edficos resultan de vital import\u00e1ncia para entender los fen\u00f3menos enzim\u00e1ticos, de transporte molecular o de transmisi\u00f3n de se\u00f1ales, as\u00ed como para el dise\u00f1o racional de f\u00e1rmacos.  en esta tesis se han estudiado distintos aspectos de los fen\u00f3menos de interacci\u00f3n ligando-receptor, tales como el efecto del solvente o la flexibilidad conformacional. Tambi\u00e9n se han aplicado distintas herramientas de la (bio)qu\u00edmica computacional al estudio de la inter-acci\u00f3n entre las huprinas (una nueva clase de inhibidores de acetilcolinesterasa) con su enzima diana. Se han establecido un modo de uni\u00f3n del inhibidor y se ha podido predecir el impacto de modificaciones qu\u00edmicas de las huprinas sobre su capacidad inhibidora.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios te\u00f3ricos de mecanismos y especificidad de interacci\u00f3n ligando-receptor<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios te\u00f3ricos de mecanismos y especificidad de interacci\u00f3n ligando-receptor <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xavier Barril Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Luque Garriga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  asuncion Alsina esteller <\/li>\n<li>federico Gago badenas (vocal)<\/li>\n<li>pelayo Camps Garc\u00eda (vocal)<\/li>\n<li>j.m. Chipot christophe (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xavier Barril Alonso La predicci\u00f3n y la comprensi\u00f3n de las interacciones entre macromol\u00e9culas biol\u00f3gicas y sus ligandos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,8036,160,115,35,199,17,560],"tags":[30211,39694,45314,11947,3286,45313],"class_list":["post-14024","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biofisica","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-fisica","category-quimica","category-quimica-fisica","tag-federico-gago-badenas","tag-francisco-javier-luque-garriga","tag-j-m-chipot-christophe","tag-maria-asuncion-alsina-esteller","tag-pelayo-camps-garcia","tag-xavier-barril-alonso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14024"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14024\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}