{"id":140357,"date":"2026-01-12T17:54:00","date_gmt":"2026-01-12T17:54:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activacion-oncogenica-en-sarcomas-musculoesqueleticos-correlaciones-clinico-patologicas\/"},"modified":"2026-01-12T17:54:00","modified_gmt":"2026-01-12T17:54:00","slug":"activacion-oncogenica-en-sarcomas-musculoesqueleticos-correlaciones-clinico-patologicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/activacion-oncogenica-en-sarcomas-musculoesqueleticos-correlaciones-clinico-patologicas\/","title":{"rendered":"Activacion oncogenica en sarcomas musculoesqueleticos. correlaciones clinico-patologicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier S\u00e1ez Castresana <\/strong><\/h2>\n<p>El presente estudio pretende aportar nuevos datos que contribuyan a definir, con una mayor aproximacion, el papel que ciertos oncogenes juegan en el desarrollo y\/o progresion de los sarcomas musculoesqueleticos. Para ello se ha estudiado una amplia serie de muestras de tumores oseos malignos y sarcomas de partes blandas, obtenidas tras cirugia. Los oncogenes c-myc, c-myb, c-h-ras y c-fms se analizaron mediante sothern blot. Se detectaron amplificaciones del oncogen c-myc en 11 de los 43 casos estudiados. La amplificacion se asocio de modo estadisticamente significativo a alto grado histologico de malignidad, estadiaje quirurgico (tumores extracompartimentales) y aumento del riesgo de recurrencia y\/o muerte en enfermos con sarcomas musculoesqueleticos. Tambien se estudiaron las mutaciones del gen oncosupresor p53 en los exones 5 a 8 mediante pcr-sscp (polimorfismos de cadena simple). Tras secuenciacion directa de los productos amplificados, se detectaron 7 tumores de 53 que presentaron un total de 11 mutaciones, mediante una variada gama de mecanismos:  sustituciones, deleciones e inserciones. El metodo sscp se mostro como valioso sustituto de la secuenciacion de dna para la deteccion de mutaciones.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activacion oncogenica en sarcomas musculoesqueleticos. correlaciones clinico-patologicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activacion oncogenica en sarcomas musculoesqueleticos. correlaciones clinico-patologicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier S\u00e1ez Castresana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ponton San Emeterio Jose<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ramon Cisterna Cancer <\/li>\n<li>Jos\u00e9 Mar\u00eda Rivera Pomar (vocal)<\/li>\n<li>Jes\u00fas Vazquez (vocal)<\/li>\n<li>Francisco Javier Pardo Mind\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier S\u00e1ez Castresana El presente estudio pretende aportar nuevos datos que contribuyan a definir, con una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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