{"id":140420,"date":"2026-01-12T17:54:31","date_gmt":"2026-01-12T17:54:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/antiagregantes-plaquetarios-en-la-prevencion-y-tratamiento-de-las-congelaciones-estudio-experimental-con-ticlopidina\/"},"modified":"2026-01-12T17:54:31","modified_gmt":"2026-01-12T17:54:31","slug":"antiagregantes-plaquetarios-en-la-prevencion-y-tratamiento-de-las-congelaciones-estudio-experimental-con-ticlopidina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/antiagregantes-plaquetarios-en-la-prevencion-y-tratamiento-de-las-congelaciones-estudio-experimental-con-ticlopidina\/","title":{"rendered":"Antiagregantes plaquetarios en la prevencion y tratamiento de las congelaciones: estudio experimental con ticlopidina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Carrasquer Sese Jos\u00e9 Antonio <\/strong><\/h2>\n<p>Introduccion: la hipotesis de que el bloqueo de la activacion plaquetaria frene la trombosis intravascular progresiva postcongelacion, mejorando la perdida de tejidos y la respuesta inflamatoria postlesional, ha propiciado el uso de antiagregantes en el tratamiento y prevencion de las congelaciones. La aminoracion de los efectos de estenosis vascular debidos a la hiperplasia endotelial inducida por factores mitogenicos liberados por las plaquetas es otra hipotesis valorada. En el momento actual, no existe acuerdo sobre el farmaco a utilizar ni sobre el momento (terapeutico o profilactico) de su empleo. Siguiendo un plan de investigacion en el seno del grupo de congelaciones del h.C.U.Z., Hemos estudiado experimentalmente la accion de la ticlopidina (t) un antiagregante plaquetario que inhibe el estimulo por adp e interfiere con el receptor plaquetario del fibrinogeno.  material y metodos: hemos sometido a 29 conejos a un procedimiento experimental de congelacion de la pata trasera a -5c y a -12c sucesivamente, segun un protocolo utilizado en nuestro laboratorio, estandarizado y ya publicado. Los animales fueron divididos en tres series (n = 8): 1.- Control (c); 2. Preventivo (a), con administracion de t 4 dias precongelacion; y o.- Terapeutico (b), con administracion de t durante 21 dias postcongelacion. La dosis de t en todos los casos fueron de 20 mg\/kg\/dia, via oral.  controles: a.- Clinicos (perdida de tejidos, edema y volumen postcongelacion, crecimiento de pelo, consolidacion de mu\u00f1on); b.- Analiticos (fibrinogeno, hemograma, estudio de coagulacion); y c.- Histologico (valoracion de la hiperplasia endotelial).  resultados y conclusiones:  1.- La administracion de t postcongelacion disminuye la perdida de tejidos, con un nivel de amputacion menor con respecto al grupo control (p &lt; 0.05); disminuye la respuesta inflamatoria medida por el grado de edema al tercer dia (p 0.05), la tasa de fibrinogeno al 25 dia (p &lt;<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Antiagregantes plaquetarios en la prevencion y tratamiento de las congelaciones: estudio experimental con ticlopidina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Antiagregantes plaquetarios en la prevencion y tratamiento de las congelaciones: estudio experimental con ticlopidina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Carrasquer Sese Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lacruz Morandeira Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ricardo Lozano Mantecon <\/li>\n<li> Lloris Carsi Jos\u00e9 Miguel (vocal)<\/li>\n<li>Martin Gutierrez Martin (vocal)<\/li>\n<li>Jacques Foray (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carrasquer Sese Jos\u00e9 Antonio Introduccion: la hipotesis de que el bloqueo de la activacion plaquetaria frene la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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