{"id":140777,"date":"2026-01-12T17:57:25","date_gmt":"2026-01-12T17:57:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-la-transferencia-de-genes-al-estudio-de-mecanismos-de-regularizacion-metabolica-en-mamiferos\/"},"modified":"2026-01-12T17:57:25","modified_gmt":"2026-01-12T17:57:25","slug":"aplicacion-de-la-transferencia-de-genes-al-estudio-de-mecanismos-de-regularizacion-metabolica-en-mamiferos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aplicacion-de-la-transferencia-de-genes-al-estudio-de-mecanismos-de-regularizacion-metabolica-en-mamiferos\/","title":{"rendered":"Aplicacion de la transferencia de genes al estudio de mecanismos de regularizacion metabolica en mamiferos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alfonso Valera Abril <\/strong><\/h2>\n<p>En primer lugar, el trabajo se ha centrado en el estudio del control de la expresion de la p-enolpiruvato carboxiquinasa, enzima clave en la gluconeogenesis, y otros genes de interes meta metabolico, inicialmente en hepatocitos en cultivo primario y posteriormente in vivo en ratas diabeticas. En segundo lugar, utilizando animales trangenicos que contenian el gen quimerico pepck\/bgh, se estudio el control de expresion del transgen con el fin de analizar las ventajas del promotor para dirigir genes de interes en regulacion metabolica.  de manera simultanea, se analizo el efecto de la exposicion cronica a hormona de crecimiento, dado que esta hormona interviene en el control de un gran numero de procesos metabolicos y su accion esta intimamente relacionada con la de la insulina.  por ultimo, se ha desarrollado una aproximacion al estudio de una posible terapia genica de la diabetes mediante la obtencion de un gen quimerico que expresa insulina humana bajo el control hormonal que le confiere el promotor de la p epck.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicacion de la transferencia de genes al estudio de mecanismos de regularizacion metabolica en mamiferos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicacion de la transferencia de genes al estudio de mecanismos de regularizacion metabolica en mamiferos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alfonso Valera Abril <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fatima Bosch Tubert<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Joan Guinovart Cirera <\/li>\n<li>Francesc Gonz\u00e1lez Sastre (vocal)<\/li>\n<li>Fausto Garcia Hegardt (vocal)<\/li>\n<li>Ricardo Pujol Borrell (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alfonso Valera Abril En primer lugar, el trabajo se ha centrado en el estudio del control de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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