{"id":140842,"date":"2026-01-12T17:57:55","date_gmt":"2026-01-12T17:57:55","guid":{"rendered":""},"modified":"2026-01-12T17:57:55","modified_gmt":"2026-01-12T17:57:55","slug":"determinacion-de-la-presencia-del-genoma-del-virus-c-de-la-hepatitis-en-suero-de-portadores-cronicos-mediante-amplificacion-genica-secuenciacion-de-los-fragmentos-amplificados-y-estudio-comparativo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/determinacion-de-la-presencia-del-genoma-del-virus-c-de-la-hepatitis-en-suero-de-portadores-cronicos-mediante-amplificacion-genica-secuenciacion-de-los-fragmentos-amplificados-y-estudio-comparativo\/","title":{"rendered":"Determinacion de la presencia del genoma del virus c. de la hepatitis en suero de portadores cronicos mediante amplificacion genica. secuenciacion de los fragmentos amplificados y estudio comparativo con los previamente descritos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Castillo Aguilar <\/strong><\/h2>\n<p>Se determina el metodo mas sensible para detectar por pcr, el vch-rna en suero de portadores cronicos, mediante comparacion de distintos metodos de aislamiento del virus, como amplificando diferentes regiones del genoma viral. Ademas se clonaron los fragmentos del vch obtenidos por pcr y se comparo la secuencia genomica del virus c con las descritas en estados unidos y japon. El mayor porcentaje de positividad al vch-rna en suero se obtuvo aislando el virus mediante isotrocianato de guanidina en frio y realizando la pcr amplificando la region ns3 del genoma viral. Tras la secuenciacion de fragmentos de la region ns5 del genoma del virus c. Se comprobo que entre el vch aislado de pacientes espa\u00f1oles y el aislado en estados unidos y japon, existia una diferencia del 21 y 7%, respectivamente a nivel de nucleotedos. Este hecho parece confirmar la posible existencia de variantes o sub-tipos del virus c, dependiendo del area geografica donde se aisle.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinacion de la presencia del genoma del virus c. de la hepatitis en suero de portadores cronicos mediante amplificacion genica. secuenciacion de los fragmentos amplificados y estudio comparativo con los previamente descritos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinacion de la presencia del genoma del virus c. de la hepatitis en suero de portadores cronicos mediante amplificacion genica. secuenciacion de los fragmentos amplificados y estudio comparativo con los previamente descritos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Castillo Aguilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Carre\u00f1o Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Segovia De Arana <\/li>\n<li>Mercedes Ruiz Moreno (vocal)<\/li>\n<li> Perez Piqueras Fco. Javier (vocal)<\/li>\n<li>Carmen Lopez Fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Castillo Aguilar Se determina el metodo mas sensible para detectar por pcr, el vch-rna en suero [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[279,494,35,5220,280,5219],"tags":[15434,255524,5535,14811,255525,14398],"class_list":["post-140842","post","type-post","status-publish","format-standard","hentry","category-bacteriofagos","category-ciencias-agrarias","category-ciencias-de-la-vida","category-fitopatologia-agricola","category-virologia","category-virus-de-las-plantas","tag-carmen-lopez-fernandez","tag-inmaculada-castillo-aguilar","tag-jose-maria-segovia-de-arana","tag-mercedes-ruiz-moreno","tag-perez-piqueras-fco-javier","tag-vicente-carreno-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/140842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=140842"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/140842\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=140842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=140842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=140842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}