{"id":140853,"date":"2026-01-12T17:57:57","date_gmt":"2026-01-12T17:57:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-los-grupos-sulfidrilo-en-el-mantenimiento-de-la-estructura-y-actividad-de-la-s-adenosil-l-metionina-sintetasa-de-higado-de-rata\/"},"modified":"2026-01-12T17:57:57","modified_gmt":"2026-01-12T17:57:57","slug":"funcion-de-los-grupos-sulfidrilo-en-el-mantenimiento-de-la-estructura-y-actividad-de-la-s-adenosil-l-metionina-sintetasa-de-higado-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/funcion-de-los-grupos-sulfidrilo-en-el-mantenimiento-de-la-estructura-y-actividad-de-la-s-adenosil-l-metionina-sintetasa-de-higado-de-rata\/","title":{"rendered":"Funcion de los grupos sulfidrilo en el mantenimiento de la estructura y actividad de la s-adenosil-l-metionina sintetasa de higado de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Jose Corrales Izquierdo <\/strong><\/h2>\n<p>La s-adenosil-l-metionina sintetasa (sam-sintetasa) es la enzima responsable de la sintesis de sam utilizando metionina y atp como sustratos. En higado de rata se encuentran dos formas de sam-sintetasa: una tetramerica y una dimerica constituidas por el mismo tipo de subunidad.  la modificacion de dos residuos sulfidrilo produce la inactivacion de ambas formas y la disociacion a dimeros de la forma tetramerica. La modificacion del residuo de cisteina 150 produce la perdida del 80% de la actividad y esta muy proximo al sitio de union para atp, por lo que se le atribuye un importante papel funcional o estructural en la catalisis. El gsh es el principal responsable del mantenimiento del potencial de oxido-reduccion celular y, por tanto, de los grupos sh de proteinas. La disminucion de los niveles hepaticos de gsh produce la perdida del 60% de la actividad sam-sintetasa, mientras que los niveles de mrna para esta enzima no se modifican. La administracion de compuestos que incrementan los niveles de gsh, como los esteres de gsh o la sam, evitan la perdida de actividad enzimatica producida por la disminucion del gsh hepatico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funcion de los grupos sulfidrilo en el mantenimiento de la estructura y actividad de la s-adenosil-l-metionina sintetasa de higado de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funcion de los grupos sulfidrilo en el mantenimiento de la estructura y actividad de la s-adenosil-l-metionina sintetasa de higado de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Jose Corrales Izquierdo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Mato De La Paz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Rod\u00e9s Teixidor <\/li>\n<li>Juan  Emilio Feliu Albi\u00f1ana (vocal)<\/li>\n<li>Juan Vi\u00f1a Ribes (vocal)<\/li>\n<li>Edgardo Catalan Tovar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Jose Corrales Izquierdo La s-adenosil-l-metionina sintetasa (sam-sintetasa) es la enzima responsable de la sintesis de sam [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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