{"id":140946,"date":"2026-01-12T17:58:34","date_gmt":"2026-01-12T17:58:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/organizacion-de-los-mecanismos-responsables-de-la-autotolerancia-implicaciones-en-el-desarrollo-de-las-enfermedades-autoinmunes\/"},"modified":"2026-01-12T17:58:34","modified_gmt":"2026-01-12T17:58:34","slug":"organizacion-de-los-mecanismos-responsables-de-la-autotolerancia-implicaciones-en-el-desarrollo-de-las-enfermedades-autoinmunes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/organizacion-de-los-mecanismos-responsables-de-la-autotolerancia-implicaciones-en-el-desarrollo-de-las-enfermedades-autoinmunes\/","title":{"rendered":"Organizacion de los mecanismos responsables de la autotolerancia: implicaciones en el desarrollo de las enfermedades autoinmunes."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guido Kroemer <\/strong><\/h2>\n<p>Este trabajo integra aisladas acerca de la fisiolog\u00eda de la autotolerancia inmune y de la patolog\u00eda de la autoagresion en un esquema general, intentando dar una vision holistica del (mal) funcionamiento de uno de los sistemas mas complejos que existe en el organismo de los vertebrados. Se propone un organigrama del sistema inmune donde varios mecanismos complementarios, jerarquizados en el tiempo, estan interconectados en serie para contener la autoagresion. Este sistema es interpretado como una secuencia de valvulas de seguridad, en la que cada dispositivo entra en funcionamiento si la valvula dispuesta en una posicion inmediatamente superior de la jerarquia falla. La idea de una homeostasis redundante de la autotolerancia es compatible con la naturaleza multicausal y la compleja etiolog\u00eda de las enfermedades autoinmunes, su desarrollo prolongado, lento-progresivo o reincidente y con la posibilidad de intervenir terapeuticamente a distintos niveles para reestablecer la autotolerancia. De esta forma, permite resolver algunas de las paradojas que son propias a la patofisiolog\u00eda del sistema inmune.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Organizacion de los mecanismos responsables de la autotolerancia: implicaciones en el desarrollo de las enfermedades autoinmunes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Organizacion de los mecanismos responsables de la autotolerancia: implicaciones en el desarrollo de las enfermedades autoinmunes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guido Kroemer <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Martinez Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Ortiz De Landazuri <\/li>\n<li>Francisco Sanchez Madrid (vocal)<\/li>\n<li>Jos\u00e9 Antonio L\u00f3pez De Castro (vocal)<\/li>\n<li>Melchor Alvarez De Mon Soto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guido Kroemer Este trabajo integra aisladas acerca de la fisiolog\u00eda de la autotolerancia inmune y de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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