{"id":140965,"date":"2026-01-12T17:58:40","date_gmt":"2026-01-12T17:58:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-funcional-de-proteinas-de-poliovirus-clonacion-y-expresion-de-la-proteasa-2a-del-virus\/"},"modified":"2026-01-12T17:58:40","modified_gmt":"2026-01-12T17:58:40","slug":"caracterizacion-funcional-de-proteinas-de-poliovirus-clonacion-y-expresion-de-la-proteasa-2a-del-virus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-funcional-de-proteinas-de-poliovirus-clonacion-y-expresion-de-la-proteasa-2a-del-virus\/","title":{"rendered":"Caracterizacion funcional de proteinas de poliovirus. clonacion y expresion de la proteasa 2a del virus."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Mart\u00ednez-abarca Pastor <\/strong><\/h2>\n<p>El virus de la polio posee un genoma de polaridad positiva y este es el unico componente virico necesario para iniciar un ciclo completo. Su replicacion tiene lugar mediante dos procesos: primero, el paso de banda + a la -, y segundo la sintesis de banda + que dara lugar a la progenie del virus. Hemos analizado varios factores que afectan este proceso, asi: el medio hipotonico inhibe la replicacion, la relacion entre la banda &#8211; y la + es de dos a tres veces superior entre lineas celulares monociticas que en celulas epiteliales y las flavonas son inhibidores especificos de la replicacion de la banda +.  por otro lado comprobamos que el genoma delecionado en la region codificadora para las proteinas estructurales es capaz de replicarse. Posteriormente nuestro estudio se centro en en analizar la funcion de la proteina 2a del virus. La hemos expresado y purificado de forma activa en e. Coli. Hemos observado, a su vez, que su expresion en celulas animales inhibe la co-expresion de genes se\u00f1uelo (reporter) e induce la rotura de la proteina celular p220, y no tiene efectos sobre la replicacion del virus de la vacuna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion funcional de proteinas de poliovirus. clonacion y expresion de la proteasa 2a del virus.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion funcional de proteinas de poliovirus. clonacion y expresion de la proteasa 2a del virus. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Mart\u00ednez-abarca Pastor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Carrasco Llamas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: C\u00e9sar Nombela Cano <\/li>\n<li>Fernando Garcia-arenal Rodriguez (vocal)<\/li>\n<li>Javier Benavente (vocal)<\/li>\n<li>Esteban Domingo Solans (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Mart\u00ednez-abarca Pastor El virus de la polio posee un genoma de polaridad positiva y este es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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