{"id":14109,"date":"2018-03-09T09:00:40","date_gmt":"2018-03-09T09:00:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-radicales-libres-y-enzimas-antioxidantes-en-la-enfermedad-por-reflujo-gastroesofagico\/"},"modified":"2018-03-09T09:00:40","modified_gmt":"2018-03-09T09:00:40","slug":"papel-de-los-radicales-libres-y-enzimas-antioxidantes-en-la-enfermedad-por-reflujo-gastroesofagico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-los-radicales-libres-y-enzimas-antioxidantes-en-la-enfermedad-por-reflujo-gastroesofagico\/","title":{"rendered":"Papel de los radicales libres y enzimas antioxidantes en la enfermedad por reflujo gastroesofagico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez Andr\u00e9s M. Teresa <\/strong><\/h2>\n<p>Los mecanismos intr\u00ednsecos por los que el \u00e1cido y la pepsina provocan da\u00f1o sobre la mucosa esof\u00e1gica no son bien conocidos. Existen escasos estudios sobre como los radicales libres est\u00e1n involucrados en la patog\u00e9nesis de la lesi\u00f3n y como influyen los sistemas antioxidantes.  objetivos  identificar la existencia de radicales libres, su fuente de producci\u00f3n, y los mecanismos de defensa en la l\u00ednea celular esof\u00e1gica het-1a, agredida con diferentes medios, y en biopsias de es\u00f3fago humano con distintos grados de lesi\u00f3n.  m\u00e9todos  las c\u00e9lulas het-1a son agredidas con h2o2, xantina-xantina oxidasa y \u00e1cido  a diferentes concentraciones y tiempos de incubaci\u00f3n, determin\u00e1ndose radicales libres mediante lipoperoxidaci\u00f3n y quimioluminescencia (lucigenina), y actividad super\u00f3xido dismutasa (sod). A partir de biopsias de es\u00f3fago humano con distintos grados de esofagitis y es\u00f3fago de barrett, medimos ani\u00f3n super\u00f3xido (.O2-) mediante quimioluminescencia, y por citometr\u00eda de flujo identificamos per\u00f3xido de hidr\u00f3geno y la fuente de producci\u00f3n del .O2-. Evaluamos en dichas biopsias actividad sod, glutation reducido y actividad catalasa.  resultados  celulas het-1a: se observa una producci\u00f3n de radicales libres por parte de estas c\u00e9lulas, siendo estad\u00edsticamente significativo cuando se agreden con xantina-xantina oxidasa y \u00e1cido a ph 7, 6.5 y 5. La actividad sod tiende a disminuir cuando el grado de acidez aumenta.  biopsias esofagicas humnas: (n=122) se produce un aumento de la generaci\u00f3n de ani\u00f3n super\u00f3xido cuando existe una mayor lesi\u00f3n esof\u00e1gica (erosi\u00f3n\/\u00falcera) (p&lt;0,05) y sobretodo en los es\u00f3fagos de barrett acompa\u00f1ados de inflamaci\u00f3n (p&lt;0,01). La principal fuente de producci\u00f3n de \u00e9ste radical es la c\u00e9lula inflamatoria (cd11b+), pero no la \u00fanica (cd11b-). Se observa la presencia de per\u00f3xido de hidr\u00f3geno en mucosa esof\u00e1gica con erosiones y \u00falceras. Estos datos se asocian a una respuesta de l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los radicales libres y enzimas antioxidantes en la enfermedad por reflujo gastroesofagico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los radicales libres y enzimas antioxidantes en la enfermedad por reflujo gastroesofagico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez Andr\u00e9s M. Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeola<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Ortego fernandez de retana <\/li>\n<li>Juan  ignacio Arenas mirave (vocal)<\/li>\n<li>ricardo Sainz samitier (vocal)<\/li>\n<li>julio Ponce Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez Andr\u00e9s M. Teresa Los mecanismos intr\u00ednsecos por los que el \u00e1cido y la pepsina provocan da\u00f1o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,13610],"tags":[45550,45551,28538,12217,18028,45549],"class_list":["post-14109","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-zaragoza","tag-angel-lanas-arbeola","tag-javier-ortego-fernandez-de-retana","tag-juan-ignacio-arenas-mirave","tag-julio-ponce-garcia","tag-ricardo-sainz-samitier","tag-sanchez-andres-m-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14109"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14109\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}