{"id":141440,"date":"2026-01-12T18:02:25","date_gmt":"2026-01-12T18:02:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/patogenia-de-la-hiperfiltracion-en-la-nefropatia-experimental-papel-del-captopril\/"},"modified":"2026-01-12T18:02:25","modified_gmt":"2026-01-12T18:02:25","slug":"patogenia-de-la-hiperfiltracion-en-la-nefropatia-experimental-papel-del-captopril","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/patogenia-de-la-hiperfiltracion-en-la-nefropatia-experimental-papel-del-captopril\/","title":{"rendered":"Patogenia de la hiperfiltracion en la nefropatia experimental. papel del captopril."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Saiz Hervas <\/strong><\/h2>\n<p>El trabajo evalua la funcion glomerular y mesangial en un modelo de diabetes experimental en ratas inyectadas con estreptozolozina. Los glomerulos de estas ratas son hipocontractiles a la angiotensina ii, paf y egf, asi como a la contraccion inducida por esteres de fabol, lo que sugiere undefecto celular intrinseco en el mecanismo de contraccion. Por otra parte, el captopril (un inhibidor de la enzima conversora de angiotensina) administrado en el agua de bebida de las ratas diabeticas a razon de 15 mg\/kg\/dia revierte parcialmente la hiporrespuesta a los esteres de fabol (probablemente mejorando los mecanismos intrinsecos de contraccion). Uno de los mecanismos responsables de la hipocontractilidad de celulas mesangiales parece ser la hiperglucemia, ya que medios hiperglucemicos condicionaron una respuesta contractil disminuida a los esteres de fabol, en tanto que medios hiperosmolares (manitol) solo redujeron la contractibilidad en peque\u00f1o grado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Patogenia de la hiperfiltracion en la nefropatia experimental. papel del captopril.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Patogenia de la hiperfiltracion en la nefropatia experimental. papel del captopril. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Saiz Hervas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Diego Rodr\u00edguez Puyol<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Melchor Alvarez De Mon Soto <\/li>\n<li>Alberto Tejedor Jorge (vocal)<\/li>\n<li>Carlos Quereda (vocal)<\/li>\n<li>Elpidio Calvo Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Saiz Hervas El trabajo evalua la funcion glomerular y mesangial en un modelo de diabetes experimental [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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