{"id":141462,"date":"2026-01-12T18:02:35","date_gmt":"2026-01-12T18:02:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/the-fibrinolytic-system-in-patients-with-diabetes-mellitus\/"},"modified":"2026-01-12T18:02:35","modified_gmt":"2026-01-12T18:02:35","slug":"the-fibrinolytic-system-in-patients-with-diabetes-mellitus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/the-fibrinolytic-system-in-patients-with-diabetes-mellitus\/","title":{"rendered":"The fibrinolytic system in patients with diabetes mellitus"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Aza Pascual Salcedo Mercedes <\/strong><\/h2>\n<p>Se ha estudiado la actividad del sistema fibrinolitico en 80 pacientes diabeticos: 25 insulin-dependientes y 55 no insulin-dependientes. La actividad fibrinolitica de las euglobulinas en placa de fibrina y t-pa funcional y antigenico fueron determinados antes y despues de la aplicacion de la prueba de la oclusion venosa; y pai-1 antigenico y funcional, pai-2 ag, alfa2- antiplasmina, plasminogeno, productos de degradacion del fibrinogeno y dimero d, previamente a la aplicacion de la misma.  con respecto al grupo control (n=30), los pacientes diabeticos presentaron una menor respuesta fibrinolitica (p=0,020) y liberacion de t-pa funcional ante el estimulo (p&lt;0,0001), con superiores valores de pai-1 funcional (p&lt;0,0001) y antigenico (p=0,019), que correlacionaron con la concentracion de insulina plasmatica (r=0,59, p&lt;0,001; r=0,46, p.0,001 respectivamente). Esta misma situacion se hallo en el grupo con diabetes mellitus no insulin-dependiente, sin verse afectada por el tratamiento recibido. Estos resultados sugieren que el sistema fibrinolitico se encuentra alterado en pacientes diabeticos, especialmente en los no insulin-dependientes, y que los elevados valores de insulina podrian jugar un papel en el desarrollo de las complicaciones vasculares a traves de un aumento en la concentracion y actividad de pai-1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>The fibrinolytic system in patients with diabetes mellitus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 The fibrinolytic system in patients with diabetes mellitus <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Aza Pascual Salcedo Mercedes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Rocha Hernando<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Edurne Cenarruzabeitia Sagarminaga <\/li>\n<li>Jos\u00e9 Antonio Paramo Fernandez (vocal)<\/li>\n<li>Ana Isabel Alcalde Herrero (vocal)<\/li>\n<li> De La Sierra Cirujeda Joaquin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aza Pascual Salcedo Mercedes Se ha estudiado la actividad del sistema fibrinolitico en 80 pacientes diabeticos: 25 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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