{"id":141577,"date":"2026-01-12T18:03:38","date_gmt":"2026-01-12T18:03:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sintesis-y-evaluacion-de-nuevos-farmacos-anticancerosos-selectivos-en-hipoxia-derivados-de-quinoxalina\/"},"modified":"2026-01-12T18:03:38","modified_gmt":"2026-01-12T18:03:38","slug":"diseno-sintesis-y-evaluacion-de-nuevos-farmacos-anticancerosos-selectivos-en-hipoxia-derivados-de-quinoxalina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diseno-sintesis-y-evaluacion-de-nuevos-farmacos-anticancerosos-selectivos-en-hipoxia-derivados-de-quinoxalina\/","title":{"rendered":"Dise\u00f1o, sintesis y evaluacion de nuevos farmacos anticancerosos, selectivos en hipoxia derivados de quinoxalina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pi\u00f1ol Rodriguez Alfonso Jose <\/strong><\/h2>\n<p>En el interior de un tumor solido, las celulas se encuentran en condiciones de hipoxia debido al espasmo vascular producido por la elevada presion intratumoral.  la hipoxia reinante en el seno del tejido es la responsable del fracaso de la radioterapia y la quimioterapia. El objeto de este trabajo es encontrar nuevos farmacos que maten mas celulas hipoxicasque oxicas.  se han sintetizado 36 compuestos derivados de quinoxalina, cuya molecula presenta analogia con la molecula del compuesto sr4233 que actualmente se encuentra en el ensayo clinico.  la valoracion biologica ha sido realizada mediante ensayo clonogenico en celulas v79 y utilizando como patrones nitracrina, mitomicina c y sr4233 sintetizado en nuestro laboratorio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, sintesis y evaluacion de nuevos farmacos anticancerosos, selectivos en hipoxia derivados de quinoxalina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, sintesis y evaluacion de nuevos farmacos anticancerosos, selectivos en hipoxia derivados de quinoxalina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pi\u00f1ol Rodriguez Alfonso Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Monge Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Sanchez Gonzalez <\/li>\n<li>Ignacio Aldana Moraza (vocal)<\/li>\n<li>Joaquin Giraldez Deiro (vocal)<\/li>\n<li> Martinez Ramirez M. Teresa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pi\u00f1ol Rodriguez Alfonso Jose En el interior de un tumor solido, las celulas se encuentran en condiciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,28949,189,484,17749,17,18],"tags":[7150,91383,17947,256288,18204,256287],"class_list":["post-141577","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-espectroscopia-de-masas","category-farmacodinamia","category-mecanismos-de-accion-de-la-quimioterapia","category-navarra","category-quimica","category-quimica-analitica","tag-antonio-monge-vega","tag-ignacio-aldana-moraza","tag-joaquin-giraldez-deiro","tag-Martinez-ramirez-m-teresa","tag-miguel-sanchez-gonzalez","tag-pinol-rodriguez-alfonso-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/141577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=141577"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/141577\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=141577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=141577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=141577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}