{"id":141593,"date":"2026-01-12T18:03:44","date_gmt":"2026-01-12T18:03:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-del-contenido-en-dna-nuclear-en-el-cancer-de-mama\/"},"modified":"2026-01-12T18:03:44","modified_gmt":"2026-01-12T18:03:44","slug":"valor-pronostico-del-contenido-en-dna-nuclear-en-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-del-contenido-en-dna-nuclear-en-el-cancer-de-mama\/","title":{"rendered":"\u00abvalor pronostico del contenido en dna nuclear en el cancer de mama\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  San Roman Machain Alberto <\/strong><\/h2>\n<p>Se ha estudiado el valor pronostico de la ploidia y de la actividad proliferativa (%s y %s + g2\/m) por citometria de flujo y analisis de imagen en 119 pacientes con carcinoma infiltrante de mama en material incluido en parafina. Los resultados se compararon con: tama\u00f1o tumoral, afectacion ganglionar, estadio clinico, tipo y grado histologico, menopausia, receptores de esteroides, expresion de filamentos intermedios de vimentina y evolucion clinica. De los 119 histogramas valorados, 43 (36%) eran diploides. Tanto la aneuploidia como la actividad proliferativa se relaciono significativamente con el grado histologico (p&lt;0,001). La ploidia tiene un valor predictivo significativo (p=0,0006) en relacion al intervalo libre de recidiva. La actividad proliferativa (%s + g2\/m) tiene un valor pronostico tanto en el intervalo libre de recidiva (p=0,024) como en la supervivencia (p=0,046). El analisis multivariado de cox mostro una dependencia entre la ploidia y el grado histologico.  la expresion de vimentina se asocia con carcinoma ductal de alto grado histologico (p&lt;0,001), aneuploidia y una elevada actividad proliferativa (p&lt;0,05). La determinacion de expresion de vimentina no tiene valor practico, dado que este antigeno es expresado solo por un bajo numero de tumores, casi todos ellos de alto grado.  por tanto, la expresion de vimentina marca un pronostico, pero su ausencia no tiene significacion alguna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abvalor pronostico del contenido en dna nuclear en el cancer de mama\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abvalor pronostico del contenido en dna nuclear en el cancer de mama\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  San Roman Machain Alberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Vazquez Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jose Rivera Pomar <\/li>\n<li>Andr\u00e9s Sampedro Mu\u00f1o (vocal)<\/li>\n<li>Francisco Javier Pardo Mind\u00e1n (vocal)<\/li>\n<li>Alfonso Sanchez Ibarrola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de San Roman Machain Alberto Se ha estudiado el valor pronostico de la ploidia y de la actividad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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