{"id":141594,"date":"2026-01-12T18:03:44","date_gmt":"2026-01-12T18:03:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/optimizacion-de-formas-intranasales-de-insulina-estudios-de-biodisponibilidad\/"},"modified":"2026-01-12T18:03:44","modified_gmt":"2026-01-12T18:03:44","slug":"optimizacion-de-formas-intranasales-de-insulina-estudios-de-biodisponibilidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/optimizacion-de-formas-intranasales-de-insulina-estudios-de-biodisponibilidad\/","title":{"rendered":"Optimizacion de formas intranasales de insulina. estudios de biodisponibilidad."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Agustina Sanchez Diaz <\/strong><\/h2>\n<p>La administracion nasal de peptidos, con problemas de biodisponibilidad por vias comunmente utilizadas enterapeutica ha sido un tema muy estudiado. La insulina debe ser formulada en presencia de tensioactivos para que el preparado nasal resultante sea biodisponible, eficaz y estable. La determinacion de la estabilidad se realiza tras su almacenamiento a distintas temperaturas, para poder predecir asi fechas de caducidad. La estimacion de la biodisponibilidad absoluta, en ratas wistar mediante curvas de nivel plasmatico obtenidas tras la administracion de bolus intravenoso y administracion intranasal de las formulaciones. Y, la valoracion de su eficacia mediante el descenso de glucemia producido en plasma de rata. Ademas, se ha comprobado si la hipoglucemia en ratas sanas es equiparable a la de ratas diabeticas. De los resultados obtenidos se puede concluir que la preparacion mas estable y eficaz es la formulada con taurocolato sodico al 1%.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Optimizacion de formas intranasales de insulina. estudios de biodisponibilidad.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Optimizacion de formas intranasales de insulina. estudios de biodisponibilidad. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Agustina Sanchez Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Ygartua Ayerra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Sanchez Gonzalez <\/li>\n<li>Jos\u00e9 Cemeli Pons (vocal)<\/li>\n<li>Daniel Fos Galve (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agustina Sanchez Diaz La administracion nasal de peptidos, con problemas de biodisponibilidad por vias comunmente utilizadas enterapeutica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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