{"id":141666,"date":"2026-01-12T18:04:19","date_gmt":"2026-01-12T18:04:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sustrato-microvascular-en-patologa%c2%ada-ocular-diabetica\/"},"modified":"2026-01-12T18:04:19","modified_gmt":"2026-01-12T18:04:19","slug":"sustrato-microvascular-en-patologa%c2%ada-ocular-diabetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/sustrato-microvascular-en-patologa%c2%ada-ocular-diabetica\/","title":{"rendered":"Sustrato microvascular en patolog\u00eda ocular diab\u00e9tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Julio Ponte Hernando <\/strong><\/h2>\n<p>Se ha estudiado la posible reproductibilidad del caso humano en el proceso degenerativo diab\u00e9tico de las estructuras oculares en diferentes cepas de ratas wistar, hechas diab\u00e9ticas mediante pancreatectom\u00eda o inyecci\u00f3n con estreptozotocina y haloxano, sustancias t\u00f3xicas selectivas contra las c\u00e9lulas beta del p\u00e1ncreas que producen una temprana y radical diabetes experimental. adem\u00e1s, se pretend\u00eda establecer un correlato inmunohistoqu\u00edmico&#8211;ultraestructural, de las variaciones celulares para identificar el\/los elementos celulares protagonistas de los cambios. se hizo una selecci\u00f3n y revisi\u00f3n exhaustiva de lo publicado por los autores m\u00e1s relevantes de la materia como cunha-vaz, cogan, de oliveira, yanoff, majno y kuwabara, etc  y mediante diversas t\u00e9cnicas de microscop\u00eda \u00f3ptica, electr\u00f3nica e inmunohistoqu\u00edmica, se lleg\u00f3 a la conclusi\u00f3n de la no viabilidad del modelo estudiado para su comparaci\u00f3n con lo que sucede en el ser humano, por cuanto: el panel de marcadores celulares e inmunohistoqu\u00edmicos no aport\u00f3 datos significativos ni se pudo establecer ning\u00fan correlato con el examen ultraestructural. La protimosina-alfa, marcador de proliferaci\u00f3n celular, ha resultado negativo a nivel de los elementos celulares de la pared de los vasos. La alteraci\u00f3n ultraestructural m\u00e1s significativa fue la presencia de lesiones mitocondriales en forma de figuras pseudomiel\u00ednicas; los mecanismos de permeabilidad de la barrera hematorretiniana se compensan mediante el fen\u00f3meno de hiperfunci\u00f3n de la macropinocitosis, en un intento de compensar la lesi\u00f3n hip\u00f3xica; no existe evidencia inmunohistoqu\u00edmica ni ultraestructural de que el engrosamiento de la membrana basal sea un factor indicativo o pron\u00f3stico de la lesi\u00f3n diab\u00e9tica en ese conjunto. Todo ello induce a pensar que todas las t\u00e9cnicas de reproducci\u00f3n de modelos experimentales del cuadro diabet\u00f3geno mediante pancreotom\u00eda, aloxano y estreptozotocina dejan muchos aspectos poco esclarecidos en cuanto a la reproducci\u00f3n del modelo experimental.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sustrato microvascular en patolog\u00eda ocular diab\u00e9tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sustrato microvascular en patolog\u00eda ocular diab\u00e9tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Julio Ponte Hernando <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/1992<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Cuevas \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Varela n\u00fa\u00f1ez <\/li>\n<li>Francisco G\u00f3mez-ulla de irazazabal (vocal)<\/li>\n<li>Jorge Teijeiro vidal (vocal)<\/li>\n<li>Andr\u00e9s Beiras iglesias (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Julio Ponte Hernando Se ha estudiado la posible reproductibilidad del caso humano en el proceso degenerativo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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