{"id":141697,"date":"2026-01-12T18:04:29","date_gmt":"2026-01-12T18:04:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-in-vitro-de-las-celulas-de-la-sangre-periferica-por-la-125oh2-d3\/"},"modified":"2026-01-12T18:04:29","modified_gmt":"2026-01-12T18:04:29","slug":"modulacion-in-vitro-de-las-celulas-de-la-sangre-periferica-por-la-125oh2-d3","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-in-vitro-de-las-celulas-de-la-sangre-periferica-por-la-125oh2-d3\/","title":{"rendered":"Modulacion in vitro de las celulas de la sangre periferica por la 1,25(oh)2-d3."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fernandez Garcia Jos\u00e9 Antonio <\/strong><\/h2>\n<p>El metabolito mas activo de la vitamina d, la 1,25-dihidroxivitamina d3 ejerce \u00abin vitro\u00bb un efecto antiproliferativo sobre las celulas mononucleares de la sangre periferica humana de donantes normales, inhibiendo su proliferacion al 50% a una concentracion de 10(e-9), la cual es una concentracion suprafisiologica. Su efecto antiproliferativo no se ejerce de forma uniforme sobre todas las subpoblaciones linfocitarias y mantiene la capacidad de estas de responder a la il-2.  la 1,25-dihidroxivitamina d3 incrementa la expresion de las moleculas vla (cuyos ligandos especificos son glicoproteinas de la matriz extracelular) y de mac-1 y la proteina p150,95; que son receptores de la fraccion c3bi del complemento en los monocitos.  sin embargo, no ejerce ninguna accion sobre la expresion de estas mismas moleculas sobre los linfocitos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion in vitro de las celulas de la sangre periferica por la 1,25(oh)2-d3.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion in vitro de las celulas de la sangre periferica por la 1,25(oh)2-d3. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fernandez Garcia Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adolfo Campos Ferrer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Merino Sanchez <\/li>\n<li>Jos\u00e9 Maria Moraleda (vocal)<\/li>\n<li>Manuel Moya Benavent (vocal)<\/li>\n<li> Gomez De La Concha Emilio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernandez Garcia Jos\u00e9 Antonio El metabolito mas activo de la vitamina d, la 1,25-dihidroxivitamina d3 ejerce \u00abin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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