{"id":141752,"date":"2026-01-12T18:05:04","date_gmt":"2026-01-12T18:05:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/induccion-de-resistencia-tumoral-a-multiples-farmacos-y-su-modulacion-en-celulas-de-leucemia-murina-p388\/"},"modified":"2026-01-12T18:05:04","modified_gmt":"2026-01-12T18:05:04","slug":"induccion-de-resistencia-tumoral-a-multiples-farmacos-y-su-modulacion-en-celulas-de-leucemia-murina-p388","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/induccion-de-resistencia-tumoral-a-multiples-farmacos-y-su-modulacion-en-celulas-de-leucemia-murina-p388\/","title":{"rendered":"Induccion de resistencia tumoral a multiples farmacos y su modulacion en celulas de leucemia murina p388"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Florentina Soto Lucas <\/strong><\/h2>\n<p>La aoaricion de resistencia a multiples farmacos antitumorales es una de los problemas mas importantes que se plantean en el tratamiento por quimioterapia. El presente trabajo se ha encaminado a elucidar mecanismo responsables de la aparicion de dicho fenotipo en celulas de leucemia de raton p388 utilizando para ello dos sublineas resistentes a la antraciclina daunomicina (r20 y r100). La alteracion funcional relacionada con la aparicion de resistencia es la acumulacion intracelular menor de farmacos en las celulas resistentes con relacion a la linea parental sensible en la linea mas resistente dicho fenomeno se explica, satisfactoriamente, por la presencia ademas de otras alteraciones de una proteina que actua como bomba de eflujo de farmacos citotoxicos desde el interior celular. En el caso de la linea celular r20, no se detecto expresion de dicha proteina, pero se han determinado otras alteraciones tales como modificacion en los valores de p ph intracelular que se postula como posible mecanismo para explicar la menor retencion de farmacos antineoplascos en la linea resistente r20.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Induccion de resistencia tumoral a multiples farmacos y su modulacion en celulas de leucemia murina p388<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Induccion de resistencia tumoral a multiples farmacos y su modulacion en celulas de leucemia murina p388 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Florentina Soto Lucas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Ferragut Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Merch\u00e1n Cifuentes Jaime A. <\/li>\n<li>Andr\u00e9s Cervantes Ruiperez (vocal)<\/li>\n<li>Adolfo Campos Ferrer (vocal)<\/li>\n<li>Francisco Jos\u00e9 Aranda Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Florentina Soto Lucas La aoaricion de resistencia a multiples farmacos antitumorales es una de los problemas mas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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