{"id":14179,"date":"2018-03-09T09:00:45","date_gmt":"2018-03-09T09:00:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-bioqua%c2%admicas-geneticas-y-medioambientales-asociadas-a-la-aparicion-de-defectos-del-tubo-neural-en-aragon\/"},"modified":"2018-03-09T09:00:45","modified_gmt":"2018-03-09T09:00:45","slug":"alteraciones-bioqua%c2%admicas-geneticas-y-medioambientales-asociadas-a-la-aparicion-de-defectos-del-tubo-neural-en-aragon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/alteraciones-bioqua%c2%admicas-geneticas-y-medioambientales-asociadas-a-la-aparicion-de-defectos-del-tubo-neural-en-aragon\/","title":{"rendered":"Alteraciones bioqu\u00edmicas, gen\u00e9ticas y medioambientales asociadas a la aparici\u00f3n de defectos del tubo neural en arag\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Ignacio Gutierrez Revilla <\/strong><\/h2>\n<p>Los defectos del tubo neural (dtns) son un conjunto de alteraciones con una preValencia importante en la ccaa de arag\u00f3n. Su etiolog\u00eda es multifactorial pudiendo interactuar, de forma conjunta o separada, factores bioqu\u00edmicos, gen\u00e9ticos y medio ambientales. A fin de estudiar dichos factores se realiz\u00f3 un estudio formado por controles, pacientes, madres y hermanos de afectos. dentro de estos grupos se estudiaron distintas pruebas bioqu\u00edmicas relacionadas con el metabolismo del folato, como las concentraciones de folato, vitamina b12, folato en c\u00e9lulas rojas y homociste\u00edna, adem\u00e1s de los polimorfismos c677t y a1298c descritos en el gen mthfr. Por \u00faltimo, se analizaron diversos factores medioambientales mediante encuesta a partir de la cual se determin\u00f3 la ingesta diet\u00e9tica de folato.  debido a la existencia de numerosos estudios en los que se establece una relaci\u00f3n entre la ingesta de preparados farmacol\u00f3gicos con \u00e1cido f\u00f3lico y la prevenci\u00f3n de ocurrencias y recurrencias de dtns, se procedi\u00f3 a su estudio mediante encuesta a 928 mujeres gestantes. Adem\u00e1s, se estudiaron distintos factores que pudieran influenciar en la correcta ingesta de \u00e1cido f\u00f3lico, as\u00ed como la ingesta diet\u00e9tica de folato.  por \u00faltimo, se ha realizado un estudio farmacoecon\u00f3mico sobre las distintas especialidades farmac\u00e9uticas compuestas por \u00e1cido f\u00f3lilco o derivados, existentes en el mercado, calcul\u00e1ndose el coste de la dosis diaria definida ajustada (ddda) a la prevenci\u00f3n de la ocurrencia de dtns. Al definir el perfil de consumo de las especialidades farmac\u00e9uticas en un subgrupo de 101 gestantes, se extrapolaron los resultados al conjunto de mujeres que dieron a luza en el a\u00f1o 2000, calcul\u00e1ndose el coste que hubiese supuesto la suplementaci\u00f3n adecuada a toda la poblaci\u00f3n de gestantes y ser comparada con la especialidad con mejor ddda.  resultados  establecidos los valores de referencia en el grupo control y la influencia de variable<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones bioqu\u00edmicas, gen\u00e9ticas y medioambientales asociadas a la aparici\u00f3n de defectos del tubo neural en arag\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones bioqu\u00edmicas, gen\u00e9ticas y medioambientales asociadas a la aparici\u00f3n de defectos del tubo neural en arag\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Ignacio Gutierrez Revilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Tamparillas Salvador<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: blanca Conde guerri <\/li>\n<li>Jos\u00e9 Miguel Garcia sagredo (vocal)<\/li>\n<li>blanca Sinues porta (vocal)<\/li>\n<li> Ferro delgado m. teresa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Ignacio Gutierrez Revilla Los defectos del tubo neural (dtns) son un conjunto de alteraciones con una 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