{"id":141854,"date":"2026-01-12T18:06:00","date_gmt":"2026-01-12T18:06:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-proteina-hha-una-nueva-familia-de-proteinas-que-modula-la-expresion-genica-en-bacterias-alterando-la-topologia-del-adn\/"},"modified":"2026-01-12T18:06:00","modified_gmt":"2026-01-12T18:06:00","slug":"la-proteina-hha-una-nueva-familia-de-proteinas-que-modula-la-expresion-genica-en-bacterias-alterando-la-topologia-del-adn","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-proteina-hha-una-nueva-familia-de-proteinas-que-modula-la-expresion-genica-en-bacterias-alterando-la-topologia-del-adn\/","title":{"rendered":"La proteina hha: una nueva familia de proteinas que modula la expresion genica en bacterias alterando la topolog\u00eda del adn."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Carmona P\u00e9rez <\/strong><\/h2>\n<p>El presente trabajo comprende una aproximacion a la comprension del mecanismo por el que la proteina hha de e. Coli modula la expresion genica. Hemos podido comprobar que los mutantes hha poseen incrementada la sintesis de alfa- hemolisina. Ademas hemos correlacionado al pleitropia de la mutacion hha con un incremento en la sintesis de proteinas heterologas a e. Coli. Asimismo, la mutacion hha se pone de manifiesto al incrementar la actividad de varios enzimas del metabolismo intermediario de e. Coli.  se ha sugerido en este trabajo la bioactividad de la proteina hha al igual que la proteina ymua de yersinia enterocolitica, con la que hha posee un 82% de hemolog\u00eda, la proteina hha esta relacionada con alteraciones \u00abin vivo\u00bb del grado de superenrrollamiento del adn. En este trabajo, ademas hemos mostrado como la osmolaridad del medio regula la sintesis de la alfa-hemolisina codificada por el plasmido ph1y 152 en e. Coli.  finalmente en este trabajo se han realizado los primeros pasos encaminados a la purificacion de la proteina hha.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La proteina hha: una nueva familia de proteinas que modula la expresion genica en bacterias alterando la topolog\u00eda del adn.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La proteina hha: una nueva familia de proteinas que modula la expresion genica en bacterias alterando la topolog\u00eda del adn. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Carmona P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Ju\u00e1rez Gim\u00e9nez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Fernando De La Cruz Calahorra <\/li>\n<li>Miguel Regu\u00e9 Queralt (vocal)<\/li>\n<li>Jos\u00e9 Pedro Martinez Garcia (vocal)<\/li>\n<li>Juan Imperial Rodenas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Carmona P\u00e9rez El presente trabajo comprende una aproximacion a la comprension del mecanismo por el que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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