{"id":14203,"date":"2018-03-09T09:00:47","date_gmt":"2018-03-09T09:00:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-por-tacrolimus-de-la-lesion-por-isquemia-reperfusion-en-un-modelo-experimental-de-trasplante-hepatico-en-cerdo\/"},"modified":"2018-03-09T09:00:47","modified_gmt":"2018-03-09T09:00:47","slug":"modulacion-por-tacrolimus-de-la-lesion-por-isquemia-reperfusion-en-un-modelo-experimental-de-trasplante-hepatico-en-cerdo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-por-tacrolimus-de-la-lesion-por-isquemia-reperfusion-en-un-modelo-experimental-de-trasplante-hepatico-en-cerdo\/","title":{"rendered":"Modulaci\u00f3n por tacrolimus de la lesi\u00f3n por isquemia-reperfusi\u00f3n en un modelo experimental de trasplante hep\u00e1tico en cerdo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Agust\u00edn Esp\u00ed Rovayo <\/strong><\/h2>\n<p>Introducci\u00f3n  los h\u00edgados procedentes de donantes en parada card\u00edaca son una alternativa para incrementar el n\u00famero de \u00f3rganos para trasplante. Sin embargo, se ven expuestos a un per\u00edodo de isquemia caliente, que acent\u00faa la lesi\u00f3n por revascularizaci\u00f3n, responsable de la disfunci\u00f3n del injerto.  el tacrolimus ha demostrado capacidad hepatoprotectora, induciendo la regeneraci\u00f3n hepatocelular y el aumento de la supervivencia en diversos modelos experimentales de lesi\u00f3n por isquemia reperfusi\u00f3n.  hip\u00f3tesis y objetivos  el experimento examina la capacidad hepatoprotectora del tacrolimus en un modelo de trasplante hep\u00e1tico con donante en asistolia.  material y m\u00e9todos  se realizaron 15 trasplantes hep\u00e1ticos en cerdo con donante sometido a 60 minutos de parada card\u00edaca. Los animales se distribuyeron en tres grupos experimentales seg\u00fan la dosis de tacrolimus administrada: controles (grupo i), 0,05 mg\/kg (grupo ii) y 0,1 mg\/kg (grupo iii). Donante y receptor fueron tratados durante los tres d\u00edas previos a cada experimento y al final de la intervenci\u00f3n. La lesi\u00f3n hep\u00e1tica se valor\u00f3 mediante una escala cuantitativa de 0 a 8 punto, utilizando 5 par\u00e1metros bioqu\u00edmicos (got y ldh, actividad de protrombina, alb\u00famina y glucemia) y 3 histopatol\u00f3gicos (necrosis, congesti\u00f3n sinusal e infiltrado inflamatorio). La funci\u00f3n mitocondrial se estudi\u00f3 cuantificando los niveles de cuerpos cet\u00f3nicos, en sangre arterial, y la concentraci\u00f3n de atp en tejido congelado. El an\u00e1lisis estad\u00edstico se llev\u00f3 a cabo mediante pruebas no param\u00e9tricas.  resultados  la puntuaci\u00f3n obtenida en la escala de valoraci\u00f3n de lesi\u00f3n hep\u00e1tica fue inferior en los grupos ii (4,2 +- 1,7) y iii (2,6 +- 2) que en el grupo control (5,4 +- 2,4), aunque estas diferencias no alcanzaron significaci\u00f3n estad\u00edstica (p=0,12). La concentraci\u00f3n de tacrolimus en sangre arterial a las 24 horas de la revascularizaci\u00f3n mostr\u00f3 una correlaci\u00f3n negativa si<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n por tacrolimus de la lesi\u00f3n por isquemia-reperfusi\u00f3n en un modelo experimental de trasplante hep\u00e1tico en cerdo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n por tacrolimus de la lesi\u00f3n por isquemia-reperfusi\u00f3n en un modelo experimental de trasplante hep\u00e1tico en cerdo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Agust\u00edn Esp\u00ed Rovayo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>cienfuegos Suarez Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andr\u00e9s Valdivieso l\u00f3pez <\/li>\n<li>daniel Casanova rituerto (vocal)<\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<li>Jes\u00fas Javier Sola gallego (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agust\u00edn Esp\u00ed Rovayo Introducci\u00f3n los h\u00edgados procedentes de donantes en parada card\u00edaca son una alternativa para incrementar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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