{"id":142205,"date":"2026-03-15T11:09:12","date_gmt":"2026-03-15T11:09:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-inmunomoduladora-del-calcitriol-efecto-sobre-la-actividad-celular-natural-killer\/"},"modified":"2026-03-15T11:09:12","modified_gmt":"2026-03-15T11:09:12","slug":"accion-inmunomoduladora-del-calcitriol-efecto-sobre-la-actividad-celular-natural-killer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/accion-inmunomoduladora-del-calcitriol-efecto-sobre-la-actividad-celular-natural-killer\/","title":{"rendered":"Accion inmunomoduladora del calcitriol: efecto sobre la \u00abactividad celular natural killer\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio Serrano Alferez <\/strong><\/h2>\n<p>La hormona secoesteroide 1,25(oh)2d3 o calcitriol es el metabolito biologicamente activo de la vitamina d.  recientes estudios muestran a esta hormona como un agente inmunomodulador. Nosotros hemos observado que el tratamiento oral con calcitriol normalizo los niveles sericos de 1,25(oh)2d3 de 18 pacientes con irc en programa de hemodialisis y produjo un incremento muy significativo de la actividad celular nk, previamente disminuida. Este incremento de la actividad celular nk era reproducible \u00abin vitro\u00bb incubando celulas mononucleares de sangre periferica, procedentes tanto de pacientes con irc como de sujetos sanos, con 1,25(oh)2d3 a 10-7 m, sugiriendo que el calcitriol ejerce esta accion actuando directamente sobre las celulas inmunes circulantes. El porcentaje de celulas fenotipicas nk (cd59+) y el porcentaje de linfocitos activados (cd25+ no se modifico por lo que probablemente el calcitriol actue directamente sobre las celulas nk.  estos resultados sugieren que el calcitriol pueden ser un agente terapeutico util para corregir las alteraciones inmunologicas presentes en la insuficiencia renal cronica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Accion inmunomoduladora del calcitriol: efecto sobre la \u00abactividad celular natural killer\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Accion inmunomoduladora del calcitriol: efecto sobre la \u00abactividad celular natural killer\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio Serrano Alferez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Solana Lara<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro S\u00e1nchez Guijo <\/li>\n<li>Carlos Lozano Tonkin (vocal)<\/li>\n<li> Alonso Diaz M. Corona (vocal)<\/li>\n<li>Francisco Rivera Hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio Serrano Alferez La hormona secoesteroide 1,25(oh)2d3 o calcitriol es el metabolito biologicamente activo de la vitamina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,973,851,1737,139],"tags":[114752,120314,14262,256917,1935,3760],"class_list":["post-142205","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-cordoba","category-endocrinologia","category-inmunologia","category-medicina-interna","tag-alonso-diaz-m-corona","tag-carlos-lozano-tonkin","tag-francisco-rivera-hernandez","tag-ignacio-serrano-alferez","tag-pedro-sanchez-guijo","tag-rafael-solana-lara"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/142205","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=142205"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/142205\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=142205"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=142205"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=142205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}