{"id":142427,"date":"2026-04-21T15:45:46","date_gmt":"2026-04-21T15:45:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hiperplasia-gingival-inducida-por-ciclosporina-a-en-trasplantados-renales-estudio-clinico-morfometrico-inmunohistoquimico-y-ultraestructural\/"},"modified":"2026-04-21T15:45:46","modified_gmt":"2026-04-21T15:45:46","slug":"hiperplasia-gingival-inducida-por-ciclosporina-a-en-trasplantados-renales-estudio-clinico-morfometrico-inmunohistoquimico-y-ultraestructural","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/hiperplasia-gingival-inducida-por-ciclosporina-a-en-trasplantados-renales-estudio-clinico-morfometrico-inmunohistoquimico-y-ultraestructural\/","title":{"rendered":"Hiperplasia gingival inducida por ciclosporina a en trasplantados renales. estudio clinico, morfometrico, inmunohistoquimico y ultraestructural."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Mesa Aguado <\/strong><\/h2>\n<p>El aumento en el tama\u00f1o de la encia es uno de los principales signos de enfermedad gingival, y la hiperplasia iatrogenica es de las causas mas frecuentes.  la csa es un farmaco introducido por borel en terapeutica en 1.976 y actualmente con un uso mas multidisciplinario (en trasplantes, enfer. Autoinmunes, patolog\u00eda tumoral).  en el presente trabajo de investigacion hacemos un estudio clinico histopatologico y con analisis digital de imagen de 30 pacientes trasplantados de ri\u00f1on de las provincias de granada y malaga, y que tomaban de forma cronica la droga. Para ello hacemos una cuantificacion de la salud oral de los pacientes. Establecemos un indice que valora de forma objetiva el grado de hiperplasia.  estudiamos mediante determinacion de la dosis serica de csa, csa \u00abin situ\u00bb, y dosis total de csa ingerida desde el trasplante. El posible papel que tiene este farmaco en la incidencia de esta patolog\u00eda oral, tipificamos y cuantificamos el infiltrado inflamatorio en la submucosa gingival mediante un panel de anticuerpos monoclopales y como hemos dicho para el indice creado, aplicamos en odontolog\u00eda una metodolog\u00eda original y facil de realizar para cuantificar el agrandamiento que es el analisis digital de imagen.  con el trabajo concluimos que: la hiperplasia cuando relacion con los indices de salud, aunque no de forma exclusiva, la poblacion de celulas inflamatorias son parecidas a las que aparecen en la enfermedad periodontal no iatrogenica, se encuentran unos depositos intralesionales que pudiera tratarse del farmaco. El mecanismo de induccion es multifactorial, aportando un modelo patogenico de induccion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hiperplasia gingival inducida por ciclosporina a en trasplantados renales. estudio clinico, morfometrico, inmunohistoquimico y ultraestructural.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hiperplasia gingival inducida por ciclosporina a en trasplantados renales. estudio clinico, morfometrico, inmunohistoquimico y ultraestructural. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Mesa Aguado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Aneiros Cachaza Jos\u00e9 Francisco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alejandro Ceballos Salobre\u00f1a <\/li>\n<li>Guillermo S\u00e1nchez Salgado (vocal)<\/li>\n<li>David Aguilar Pe\u00f1a (vocal)<\/li>\n<li>Gonzalo Hern\u00e1ndez Vallejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Mesa Aguado El aumento en el tama\u00f1o de la encia es uno de los principales signos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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